Greater cognitive deterioration in women than men with Alzheimer's disease: A meta analysis

Studies reporting on the cognitive abilities of men and women with Alzheimer's disease (AD) are surprisingly rare. We carried out a meta-analysis of neurocognitive data from 15 studies (n = 828 men; 1,238 women), which revealed a consistent male advantage on verbal and visuospatial tasks and te...

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Bibliographic Details
Published inJournal of clinical and experimental neuropsychology Vol. 34; no. 9; pp. 989 - 998
Main Authors Irvine, Karen, Laws, Keith R., Gale, Tim M., Kondel, Tejinder K.
Format Journal Article
LanguageEnglish
Published Hove Taylor & Francis Group 01.01.2012
Psychology Press
Subjects
Adult and adolescent clinical studies
Age
Alzheimer Disease - complications
Alzheimer's disease
Biological and medical sciences
Cognition
Cognition Disorders - complications
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Humans
Male
Medical sciences
Neurology
Neuropsychological Tests
Organic mental disorders. Neuropsychology
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Sex differences
Sex Distribution
Sex Factors
Space Perception
Verbal abilities
Verbal Behavior
Visuospatial abilities
Human
Nervous system diseases
Cognitive disorder
Alzheimer disease
Sex
Spatial ability
Male
Sex differences
Cognition
Review
Cerebral disorder
Metaanalysis
Intellectual deterioration
Verbal ability
Language
Central nervous system disease
Female
Degenerative disease
Woman
Visuospatial abilities
Alzheimer's disease
Verbal abilities
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Summary:Studies reporting on the cognitive abilities of men and women with Alzheimer's disease (AD) are surprisingly rare. We carried out a meta-analysis of neurocognitive data from 15 studies (n = 828 men; 1,238 women), which revealed a consistent male advantage on verbal and visuospatial tasks and tests of episodic and semantic memory. Moderator regression analyses showed that age, education level, and dementia severity did not significantly predict the male advantage. Reasons posited for this advantage include a reduction of estrogen in postmenopausal women, sex differences in AD pathology, and greater cognitive reserve in men.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:1380-3395
1744-411X
DOI:10.1080/13803395.2012.712676