Crossed-reflex in antiphospholipid chorea

• Published in: Neurological sciences Vol. 45; no. 9; pp. 4635 - 4637
• Main Authors: Fernández-Vidal, Joan Miquel, Olmedo-Saura, Gonzalo, Querol-Gutiérrez, Luis Antonio, Kulisevsky, Jaime, Pérez-Pérez, Jesús
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.09.2024; Springer Nature B.V
• Subjects: Aged; Antibodies; Anticoagulants; Antiphospholipid syndrome; Antiphospholipid Syndrome - complications; Autoimmune diseases; Chorea; Chorea - etiology; Chorea - physiopathology; Conflicts of interest; Glycoproteins; Hospitals; Humans; Male; Medicine; Medicine & Public Health; Movement disorders; Neuro-Images; Neurology; Neuromuscular diseases; Neuroradiology; Neurosurgery; Pathophysiology; Patients; Psychiatry; Reflex - physiology; Senescence; Thrombosis; Crossed-reflex; Chorea; Antiphospholipid syndrome
• ISSN: 1590-1874; 1590-3478; 1590-3478
• DOI: 10.1007/s10072-024-07622-5

Chorea is a hyperkinetic movement disorder associated with various underlyingconditions, including autoimmune diseases such as antiphospholipid syndrome (APS). APS can manifest with a wide range of neurological symptoms, including chorea. We present a case of a 77-year-old man with subacute generalized chorea secondary to primary APS. Notably, the patient exhibited a left patellar crossed-reflex, a phenomenon rarely documented in chorea cases, the pathophysiology of which has not yet been elucidated. In summary, this case challenges the traditional demographics of antiphospholipid syndrome (APS) by suggesting a potential link between APS and late-age patients. It emphasizes the importance of considering APS in late-onset chorea cases.