Role of Sam68 as an adaptor protein in inflammatory signaling

• Published in: Cellular and molecular life sciences : CMLS Vol. 81; no. 1; p. 89
• Main Authors: Gowd, Vemana, Kass, Joseph D’Amato, Sarkar, Nandini, Ramakrishnan, Parameswaran
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.12.2024; Springer Nature B.V
• Subjects: Adapters; Adaptor proteins; Apoptosis; Arthritis; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cancer; Cell adhesion & migration; Cell Biology; Cell cycle; Cell growth; Inflammation; Inflammatory bowel disease; Inflammatory diseases; Kinases; Life Sciences; Localization; Metabolism; Methylation; Phosphorylation; Protein turnover; Proteins; Review; Ribonucleic acid; RNA; RNA-binding protein; Roles; Signal transduction; Tumor necrosis factor-TNF; Tyrosine; Inflammatory bowel disease; BCR; TCR; Cardiovascular disease; Inflammation; Arthritis; TLR; TNF; Sam68
• ISSN: 1420-682X; 1420-9071
• DOI: 10.1007/s00018-023-05108-9

Sam68 is a ubiquitously expressed KH-domain containing RNA-binding protein highly studied for its involvement in regulating multiple steps of RNA metabolism. Sam68 also contains multiple protein–protein interaction regions such as proline-rich regions, tyrosine phosphorylation sites, and arginine methylation sites, all of which facilitate its participation as an adaptor protein in multiple signaling pathways, likely independent of its RNA-binding role. This review focuses on providing a comprehensive report on the adaptor roles of Sam68 in inflammatory signaling and inflammatory diseases. The insights presented here have the potential to open new avenues in inflammation research and justify targeting Sam68 to control aberrant inflammatory responses.