High-Dose Rate Salvage Interstitial Brachytherapy: A Case-Based Guide to the Treatment of Therapeutically Challenging Recurrent Vulvar Cancer

Vulvar cancer is a rare gynecological malignancy with incidence rates steadily increasing over the past 10 years. Despite aggressive treatment, recurrent disease is common. Vulvar cancer recurrence poses a significant therapeutic challenge as most patients have been previously treated with surgery a...

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Bibliographic Details
Published inFrontiers in oncology Vol. 7; p. 224
Main Authors Hughes, Kelly Eileen, McLaughlin, Christopher M, Fields, Emma C
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers Media S.A 20.09.2017
Subjects
brachytherapy
high-dose rate brachytherapy
Oncology
recurrent vulvar cancer
salvage interstitial brachytherapy
vulvar cancer
recurrent vulvar cancer
high-dose rate brachytherapy
brachytherapy
salvage interstitial brachytherapy
vulvar cancer
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Summary:Vulvar cancer is a rare gynecological malignancy with incidence rates steadily increasing over the past 10 years. Despite aggressive treatment, recurrent disease is common. Vulvar cancer recurrence poses a significant therapeutic challenge as most patients have been previously treated with surgery and/or radiation limiting the options for additional treatment. There are no consensus guidelines for the treatment of recurrent disease. Current literature supports the use of salvage interstitial brachytherapy. However, the total sample size is small. The goal of this case report is to review the current literature and to provide a guide for the use of salvage interstitial brachytherapy for recurrent disease by describing, in detail, the techniques used to treat two patients with unique cases of vulvar cancer recurrences in women with advanced disease and multiple medical comorbidities.
Bibliography:Reviewed by: John Maclou Longo, Medical College of Wisconsin, United States; Surbhi Grover, University of Pennsylvania, United States
Edited by: Daniel Grant Petereit, Rapid City Regional Hospital, United States
Specialty section: This article was submitted to Radiation Oncology, a section of the journal Frontiers in Oncology
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2017.00224