Comparison of Intralesional Placentrex Versus Hyaluronidase and Dexamethasone Injection in the Symptomatic Management of Stage II Oral Submucous Fibrosis - a Prospective Study

• Published in: Indian journal of otolaryngology, and head, and neck surgery Vol. 75; no. 4; pp. 3530 - 3534
• Main Authors: EK, Joshna, John, Bobby, Sharma, Ankit, Poorna T, Anish, Pangarikar, Anunay, Raj, Vishnu
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01.12.2023; Springer Nature B.V
• Subjects: Head and Neck Surgery; Medicine; Medicine & Public Health; Original; Original Article; Otolaryngology; Otorhinolaryngology; dexamethasone; placentrex; hyaluronidase; Oral submucous fibrosis
• ISSN: 2231-3796; 0973-7707
• DOI: 10.1007/s12070-023-04016-5

Aim: The present study aimed to compare the effectiveness of intralesional placentrex versus hyaluronidase + dexamethasone injection in the symptomatic management of stage II OSMF. Materials and Methods: This was a non-randomized prospective study conducted over a period of 14 months at a tertiary referral center. Patients with clinical stage II OSMF were randomly grouped into A(n = 18) and B(n = 17). These patients were treated with weekly intralesional injection of placentrex and hyaluronidase + dexamethasone respectively, over a period of six weeks. Variables such as mouth opening, burning sensation and colour of mucosa were evaluated at baseline(T0), second week(T1), fourth week(T3), sixth week(T4) of follow up. A p-value < 0.05 was considered statistically significant. Results: A total of 15 patients completed the study in each group with regular follow up. The mean improvement in mouth opening was 4.3 ± 0.57 mms in group A(p-value < 0.001) and 7.2 ± 0.76 mms in group B(p-value < 0.001) which were significant at the end of six weeks. Mean change in burning sensation at the end of six weeks in group A was 1.2 ± 0.73(p-value < 0.001), and 3.6 ± 0.63(p-value < 0.001) in group B. Mean change in colour of mucosa at the end of six weeks was 1.4 in group A(p-value > 0.05) and 2 in group B(p-value > 0.05). On comparison between both groups, patients in group B exhibited better mouth opening and reduction of burning sensation than patients in group A(p-value < 0.001). Conclusion: Both intralesional placentrex and hyaluronidase + dexamethasone injection are effective in alleviating the symptoms of stage II OSMF. However, hyaluronidase + dexamethasone injection showed slightly better improvement in mouth opening and burning sensation after six weeks.