Shear-induced platelet activation and platelet microparticle formation in native human blood

• Published in: Thrombosis research Vol. 92; no. 6; pp. S33 - S41
• Main Authors: Sakariassen, Kjell S., Holme, Pl A., Ørvim, Una, Marius Barstad, R., Solum, Nils O., Brosstad, Frank R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 15.12.1998
• Subjects: Adult; Blood Platelets - physiology; Blood Platelets - ultrastructure; Cytoplasmic Granules - physiology; Cytoplasmic Granules - ultrastructure; FITC; fluorescein isothiocyanate; Humans; Mab; Male; Microparticle formation; monoclonal antibody; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex - physiology; Shear; Shear activation; Stress, Mechanical; Thrombus formation; von Willebr and factor; vWF; Thrombus formation; FITC; Shear; vWF; Shear activation; Microparticle formation; Mab

Shear-induced platelet activation and platelet microparticle formation are triggered in native human blood by high arterial shear or by a sudden increase in shear as introduced by a stenosis with potential consequences for collagen-induced platelet thrombus formation. Blood was drawn from healthy vo...