Alteration by vanadate of contractility in vascular and intestinal smooth muscle preparations

Intestinal muscle was more sensitive than vascular muscle to vanadate. Vanadate caused a biphasic response in intestinal muscle; inhibition of spontaneous contractile activity was followed by a return of phasic contractions and a sustained increase in baseline tension. Then inhibitory response appea...

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Bibliographic Details
Published inPharmacology Vol. 23; no. 3; p. 156
Main Authors Hudgins, P M, Bond, G H
Format Journal Article
LanguageEnglish
Published Switzerland 01.01.1981
Subjects
Animals
Aorta, Thoracic - drug effects
Calcium-Transporting ATPases - metabolism
In Vitro Techniques
Intestines - drug effects
Muscle Contraction - drug effects
Muscle, Smooth - drug effects
Ouabain - pharmacology
Potassium - metabolism
Rabbits
Sodium - metabolism
Sodium-Potassium-Exchanging ATPase - metabolism
Vanadates
Vanadium - pharmacology
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Summary:Intestinal muscle was more sensitive than vascular muscle to vanadate. Vanadate caused a biphasic response in intestinal muscle; inhibition of spontaneous contractile activity was followed by a return of phasic contractions and a sustained increase in baseline tension. Then inhibitory response appeared to be due to vanadate-induced release of an inhibitory transmitter from intramural nerve endings. The excitatory response appeared to be due to the action of vanadate at an intracellular site, possibly by inhibition of a Ca-ATPase that controls intracellular Ca2+ levels. Vanadate did not alter intracellular Na+ and K+ levels in isolated longitudinal muscle. Thus, inhibition of intestinal muscle NaK-ATPase cannot account for the alterations in contractility.
ISSN:0031-7012
DOI:10.1159/000137544