Pathways for protein folding: is a new view needed?

Theoretical studies using simplified models of proteins have shed light on the general heteropolymeric aspects of the folding problem. Recent work has emphasized the statistical aspects of folding pathways. In particular, progress has been made in characterizing the ensemble of transition state conf...

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Bibliographic Details
Published inCurrent opinion in structural biology Vol. 8; no. 1; pp. 68 - 79
Main Authors Pande, Vijay S, Grosberg, Alexander Yu, Tanaka, Toyoichi, Rokhsar, Daniel S
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.1998
Subjects
Computer Simulation
Protein Conformation
Protein Folding
Proteins - chemistry
Thermodynamics
p fold
Q
C
N native state
U
R g
molten globule
K
CI2
F int
TS
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Summary:Theoretical studies using simplified models of proteins have shed light on the general heteropolymeric aspects of the folding problem. Recent work has emphasized the statistical aspects of folding pathways. In particular, progress has been made in characterizing the ensemble of transition state conformations and elucidating the role of intermediates. These advances suggest a reconciliation between the new ensemble approaches and the classical view of a folding pathway.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
ISSN:0959-440X
1879-033X
DOI:10.1016/S0959-440X(98)80012-2