Suppressive effect of electromagnetic field on analgesic activity of tramadol in rats
The electromagnetic fields (EMFs) have been shown to alter animal and human behavior, such as directional orientation, learning, pain perception (nociception or analgesia) and anxiety-related behaviors. The aim of this study was to evaluate the influence of electromagnetic fields of high-frequency m...
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Published in | Polish journal of veterinary sciences Vol. 15; no. 1; pp. 95 - 100 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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Germany
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01.01.2012
Polish Academy of Sciences, Committee of Veterinary Sciences |
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Abstract | The electromagnetic fields (EMFs) have been shown to alter animal and human behavior, such as directional orientation, learning, pain perception (nociception or analgesia) and anxiety-related behaviors. The aim of this study was to evaluate the influence of electromagnetic fields of high-frequency microwaves on pain perception and anti-nociceptive activity of tramadol (TRAM) - analgetic effective in the treatment of moderate to severe acute and chronic pain states. Electromagnetic fields exposures of a)1500 MHz frequency and b) modulated, 1800 MHz (which is identical to that generated by mobile phones) were applied. Paw withdrawal latency (PWL) to thermal stimulus was measured in vehicle or tramadol (TRAM) treated animals before and after 30, 60 and 90 minutes from injections. The differences in the level of pain (PWL) between control group and rats exposed to EMF alone in three measurements, were not observed. Tramadol alone significantly increased PWLs to thermal stimulus in comparison to vehicle results at 30 (p < 0.001) and 60 minutes (p < 0.05) after drug injection. EMF exposure of both frequencies transiently suppressed analgesic effect of tramadol, significantly reducing paw withdrawal latency in animals treated with this drug at 30 minutes from the drug injection. |
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AbstractList | The electromagnetic fields (EMFs) have been shown to alter animal and human behavior, such as directional orientation, learning, pain perception (nociception or analgesia) and anxiety-related behaviors. The aim of this study was to evaluate the influence of electromagnetic fields of high-frequency microwaves on pain perception and anti-nociceptive activity of tramadol (TRAM) - analgetic effective in the treatment of moderate to severe acute and chronic pain states. Electromagnetic fields exposures of a)1500 MHz frequency and b) modulated, 1800 MHz (which is identical to that generated by mobile phones) were applied. Paw withdrawal latency (PWL) to thermal stimulus was measured in vehicle or tramadol (TRAM) treated animals before and after 30, 60 and 90 minutes from injections. The differences in the level of pain (PWL) between control group and rats exposed to EMF alone in three measurements, were not observed. Tramadol alone significantly increased PWLs to thermal stimulus in comparison to vehicle results at 30 (p < 0.001) and 60 minutes (p < 0.05) after drug injection. EMF exposure of both frequencies transiently suppressed analgesic effect of tramadol, significantly reducing paw withdrawal latency in animals treated with this drug at 30 minutes from the drug injection. |
Author | Sobiech, J. Zdanowski, R. Kieliszek, J. Siwicki, A. Paluch, M. Bodera, P. Stankiewicz, W. Antkowiak, B. Wojdas, A. Skopińska-Różewska, E. |
Author_xml | – sequence: 1 givenname: P. surname: Bodera fullname: Bodera, P. organization: Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163, Warsaw, Poland1 – sequence: 2 givenname: W. surname: Stankiewicz fullname: Stankiewicz, W. organization: Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163, Warsaw, Poland1 – sequence: 3 givenname: B. surname: Antkowiak fullname: Antkowiak, B. organization: Department of Pharmacology and Toxicology, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163, Warsaw, Poland2 – sequence: 4 givenname: M. surname: Paluch fullname: Paluch, M. organization: Department of Pharmacology and Toxicology, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163, Warsaw, Poland2 – sequence: 5 givenname: J. surname: Kieliszek fullname: Kieliszek, J. organization: Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163, Warsaw, Poland1 – sequence: 6 givenname: J. surname: Sobiech fullname: Sobiech, J. organization: Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163, Warsaw, Poland1 – sequence: 7 givenname: R. surname: Zdanowski fullname: Zdanowski, R. organization: Department of Pharmacology and Toxicology, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163, Warsaw, Poland2 – sequence: 8 givenname: A. surname: Wojdas fullname: Wojdas, A. organization: Department of Otolaryngology, Szaserów 128, 04-349 Warsaw, Poland3 – sequence: 9 givenname: A. surname: Siwicki fullname: Siwicki, A. organization: Department of Microbiology and Clinical Immunology, University of Warmia and Mazury, Oczapowskiego 13, 10-957, Olsztyn, Poland4 – sequence: 10 givenname: E. surname: Skopińska-Różewska fullname: Skopińska-Różewska, E. |
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Cites_doi | 10.1213/01.ANE.0000150961.24747.98 10.1080/15368370500205431 10.1093/jat/21.7.529 10.2165/00003495-199700532-00007 10.1203/00006450-200210000-00023 10.3109/00207450108986507 |
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SubjectTerms | Analgesia Analgesics, Opioid - pharmacology Animals electromagnetic field Electromagnetic Fields Male Pain - drug therapy pain perception Rats Rats, Wistar Sensory Thresholds tramadol Tramadol - pharmacology |
Title | Suppressive effect of electromagnetic field on analgesic activity of tramadol in rats |
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