Suppressive effect of electromagnetic field on analgesic activity of tramadol in rats

The electromagnetic fields (EMFs) have been shown to alter animal and human behavior, such as directional orientation, learning, pain perception (nociception or analgesia) and anxiety-related behaviors. The aim of this study was to evaluate the influence of electromagnetic fields of high-frequency m...

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Bibliographic Details
Published inPolish journal of veterinary sciences Vol. 15; no. 1; pp. 95 - 100
Main Authors Bodera, P., Stankiewicz, W., Antkowiak, B., Paluch, M., Kieliszek, J., Sobiech, J., Zdanowski, R., Wojdas, A., Siwicki, A., Skopińska-Różewska, E.
Format Journal Article
LanguageEnglish
Published Germany Versita 01.01.2012
Polish Academy of Sciences, Committee of Veterinary Sciences
Subjects
Analgesia
Analgesics, Opioid - pharmacology
Animals
electromagnetic field
Electromagnetic Fields
Male
Pain - drug therapy
pain perception
Rats
Rats, Wistar
Sensory Thresholds
tramadol
Tramadol - pharmacology
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Summary:The electromagnetic fields (EMFs) have been shown to alter animal and human behavior, such as directional orientation, learning, pain perception (nociception or analgesia) and anxiety-related behaviors. The aim of this study was to evaluate the influence of electromagnetic fields of high-frequency microwaves on pain perception and anti-nociceptive activity of tramadol (TRAM) - analgetic effective in the treatment of moderate to severe acute and chronic pain states. Electromagnetic fields exposures of a)1500 MHz frequency and b) modulated, 1800 MHz (which is identical to that generated by mobile phones) were applied. Paw withdrawal latency (PWL) to thermal stimulus was measured in vehicle or tramadol (TRAM) treated animals before and after 30, 60 and 90 minutes from injections. The differences in the level of pain (PWL) between control group and rats exposed to EMF alone in three measurements, were not observed. Tramadol alone significantly increased PWLs to thermal stimulus in comparison to vehicle results at 30 (p < 0.001) and 60 minutes (p < 0.05) after drug injection. EMF exposure of both frequencies transiently suppressed analgesic effect of tramadol, significantly reducing paw withdrawal latency in animals treated with this drug at 30 minutes from the drug injection.
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ISSN:1505-1773
2300-2557
DOI:10.2478/v10181-011-0119-3