Relative vulnerability of the brain and spinal cord to ischemia

In this experiment CER and SER were monitored as blood flow was progressively lowered by lowering the systemic arterial pressure below the lower limits of autoregulation (bleeding). Blood flow in the brain and dorsal column of the spinal cord was monitored and recorded with the hydrogen clearance me...

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Published inJournal of the neurological sciences Vol. 45; no. 1; pp. 65 - 72
Main Authors Kobrine, Arthur I., Evans, Delbert E., Rizzoli, Hugo V.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.1980
Subjects
Animals
Blood Pressure
Brain Ischemia - physiopathology
Cerebral Cortex - physiopathology
Cerebrovascular Circulation
Evoked Potentials
Haplorhini
Ischemia - physiopathology
Macaca fascicularis
Nerve Fibers - physiology
Neural Conduction
Spinal Cord - blood supply
Spinal Cord - physiopathology
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Summary:In this experiment CER and SER were monitored as blood flow was progressively lowered by lowering the systemic arterial pressure below the lower limits of autoregulation (bleeding). Blood flow in the brain and dorsal column of the spinal cord was monitored and recorded with the hydrogen clearance method. Long tract neural conduction in the spinal cord appeared quite refractory to the effects of ischemia and disappeared only after 8–18 min of essentially absolute ischemia. The CER was more sensitive to the effects of ischemia, disappearing first in one animal and returning later in all of the animals. The SER returned in all animals after re-infusion of the blood and re-establishment of the blood flow even after a 13–23 min period of absolute ischemia and a 5 min period of electrical silence.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-510X
1878-5883
DOI:10.1016/S0022-510X(80)80007-4