The usefulness of the bioconcentration factor as a tool for priority setting in chemicals control

• Published in: Toxicology letters Vol. 168; no. 2; pp. 113 - 120
• Main Authors: Nordberg, Anna, Rudén, Christina
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 30.01.2007; Amsterdam Elsevier Science
• Subjects: Bioaccumulation; Biological and medical sciences; Carcinogens - chemistry; Carcinogens - toxicity; Chemicals control; Databases, Factual; Environmental Pollutants - chemistry; Environmental Pollutants - toxicity; Environmental Pollution - legislation & jurisprudence; Environmental Pollution - prevention & control; Historieämnen; Historisk-filosofiska ämnen; History and philosophy subjects; History of technology and industry; History subjects; HUMANIORA och RELIGIONSVETENSKAP; HUMANITIES and RELIGION; Medical sciences; Mutagens - chemistry; Mutagens - toxicity; Priority setting; REACH; Reproduction - drug effects; Risk Assessment; Teknik- och industrihistoria; Test strategies; Tiered testing; Toxicology; REACH; Tiered testing; Bioaccumulation; Risk assessment; Priority setting; Chemicals control; Test strategies; Priority; Medical screening; Epidemiology; Registration, Evaluation and Autorisation of Chemicals regulation; Risk factor; Chemical control
• ISSN: 0378-4274; 1879-3169; 1879-3169
• DOI: 10.1016/j.toxlet.2006.11.004

The implementation of the REACH system will lead to the creation of a single, uniform legislation for industrial chemicals in Europe. An important aim of this legislation is to generate toxicity data for previously untested chemicals. Testing tens of thousands of chemicals can however not be done in one step, and criteria for priority setting is therefore an essential part of the proposed REACH system. In this study we investigate potential consequences of using bioaccumulation (B) data as a tool for priority setting in chemicals control. The results of this investigation suggests that the use of data for the bioconcentration factor (BCF, as an estimation of B) at first tier will not introduce bias towards a particular type of toxicity (i.e. carcinogenicity, reproductive toxicity or mutagenicity) in the priority setting process.