Usefulness of Toxoplasma gondii recombinant antigens (GRA1, GRA7 and SAG1) in an immunoglobulin G avidity test for the serodiagnosis of toxoplasmosis

• Published in: Parasitology research (1987) Vol. 100; no. 2; pp. 333 - 337
• Main Authors: PIETKIEWICZ, H, HISZCZYNSKA -SAWICKA, E, KUR, J, PETERSEN, E, NIELSEN, H. V, PAUL, M, STANKIEWICZ, M, MYJAK, P
• Format: Journal Article
• Language: English
• Published: Berlin Springer 01.01.2007
• Subjects: Animals; Antibody Affinity; Antigens, Protozoan - immunology; Biological and medical sciences; Fundamental and applied biological sciences. Psychology; General aspects; General aspects and techniques. Study of several systematic groups. Models; Immunoglobulin G; Invertebrates; Protozoan Proteins - immunology; Sensitivity and Specificity; Serologic Tests - methods; Toxoplasma - metabolism; Toxoplasma gondii; Toxoplasmosis - diagnosis; Toxoplasmosis - immunology; Infection; Antigen; Protozoa; Apicomplexa; Protozoal disease; Immunoglobulins; Toxoplasma gondii; Toxoplasmosis; Parasite; Parasitosis
• ISSN: 0932-0113; 1432-1955
• DOI: 10.1007/s00436-006-0265-1

The precise diagnosis of an acute and recent Toxoplasma infection in pregnant women and the newborn child is important before treatment. This study describes a new Toxoplasma gondii IgG avidity test based on a combination of recombinant GRA1, GRA7 and SAG1 antigens and shows that this test is useful for diagnostic purposes and may replace the lysed, whole-cell antigens. Although more sera need to be tested, the results obtained here suggest that the IgG avidity test performed with rec-antigens correlated more with the stage of a T. gondii infection than the IgG avidity results obtained with the lysed, whole-cell antigen test, the VIDAS Toxo IgG avidity (bioMérieux).