Mild copper-catalyzed trifluoromethylation of terminal alkynes using an electrophilic trifluoromethylating reagent
A catalytic process for trifluoromethylation of terminal alkynes with Togni’s reagent has been developed, affording trifluoromethylated acetylenes in good to excellent yields. The reaction is conducted at room temperature and exhibits tolerance to a range of functional groups. [Display omitted]
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Published in | Tetrahedron Vol. 68; no. 11; pp. 2527 - 2531 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier Ltd
18.03.2012
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | A catalytic process for trifluoromethylation of terminal alkynes with Togni’s reagent has been developed, affording trifluoromethylated acetylenes in good to excellent yields. The reaction is conducted at room temperature and exhibits tolerance to a range of functional groups.
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0040-4020 1464-5416 |
DOI: | 10.1016/j.tet.2011.12.085 |