Persistence of Neointimal Growth 12 Months After Intervention and Occurrence of Delayed Restenosis in Patients With Left Main Coronary Artery Disease Treated With Drug-Eluting Stents

• Published in: Journal of the American College of Cardiology Vol. 47; no. 7; pp. 1491 - 1494
• Main Authors: Valgimigli, Marco, Malagutti, Patrizia, van Mieghem, Carlos A.G., Vaina, Sophia, Ligthart, Jurgen M., Sianos, George, Serruys, Patrick W.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.04.2006; Elsevier Limited
• Subjects: Adult; Aged; Angioplasty; Cardiology; Cardiovascular Agents - administration & dosage; Cardiovascular Agents - therapeutic use; Cardiovascular disease; Coronary Angiography; Coronary Artery Disease - physiopathology; Coronary Artery Disease - therapy; Coronary Restenosis - diagnostic imaging; Coronary Restenosis - physiopathology; Coronary vessels; Female; Heart attacks; Humans; Male; Middle Aged; Stents; Time Factors; Tunica Intima - diagnostic imaging; Tunica Intima - growth & development
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/j.jacc.2006.01.008

The reason for repeating a second coronary angiogram included risk-stratification before non-cardiac major surgery in three (Patients #1, #6, and #14), evidence of inducible ischemia at noninvasive stress test in two (Patients #4 and #15), a staged procedure for the treatment of the right coronary artery in one (Patient #13), and the willingness to repeat a second coronary angiogram in the remaining nine after counselling about the potential consequence of in-stent restenosis at the time of the index procedure. V-stent Post-dilation Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes Yes No Yes No Yes Final kissing No No No Yes No No No No No No No No Yes No Yes QCA post-PCI                RVD (mm) 3.95 3.05 3.40 2.61 3.42 3.58 3.68 2.89 3.16 3.43 2.42 3.40 2.70 3.53 2.89 MLD (mm) 3.57 3.04 2.77 2.56 3.41 2.91 3.60 2.89 2.49 3.11 2.43 2.95 2.26 3.51 2.71 Vessel stenosis (%) 10 0 18 2 0 19 2 0 21 9 0 13 16 6 6 QCA at 6-month follow-up                RVD (mm) 3.89 3.12 3.9 2.67 3.52 3.38 3.53 3.04 2.67 3.59 2.45 3.93 2.24 3.59 2.61 MLD (mm) 3.51 3.04 3.09 2.49 3.21 3.28 2.99 1.96 2.07 3.33 2.01 3.64 1.86 3.11 2.27 Vessel stenosis (%) 10 3 21 7 9 3 15 35 22 7 18 7 17 13 13 QCA at 12-month follow-up                RVD (mm) 3.79 2.74 3.45 2.50 3.20 3.44 3.12 3.12 2.66 3.26 2.55 3.37 3.17 3.78 2.58 MLD (mm) 2.84 2.70 2.40 2.37 2.18 3.12 2.87 1.92 1.95 2.99 1.62 2.81 1.03 3.01 2.27 Vessel stenosis (%) 25 1 29 5 31 9 8 38 27 8 36 17 81 20 12 Table 1 Baseline and Procedural Characteristics and Serial Quantitative Coronary Analysis of the Main Treated Branch LMCA = left main coronary artery; MLD = minimal lumen diameter; PCI = percutaneous coronary intervention; PES = paclitaxel-eluting stent; QCA = quantitative coronary analysis; RVD = reference vessel diameter; SA = stable angina; SES = sirolimus-eluting stent; STEMI = ST-segment elevation myocardial infarction; UA = unstable angina followed by Braunwald classification.