The role of exosomes in cancer metastasis

Abstract Exosomes are small membrane vesicles with a size ranging from 40 to 100 nm. They can serve as functional mediators in cell interaction leading to cancer metastasis. Metastasis is a complex multistep process of cancer cell invasion, survival in blood vessels, attachment to and colonization o...

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Bibliographic Details
Published inSeminars in cancer biology Vol. 44; pp. 170 - 181
Main Authors Steinbichler, Teresa Bernadette, Dudás, József, Riechelmann, Herbert, Skvortsova, Ira-Ida
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2017
Subjects
Cancer-associated fibroblasts
EMT
Exosomes - genetics
Exosomes - pathology
Hematology, Oncology and Palliative Medicine
Humans
Liquid Biopsy
Neoplasm Metastasis - genetics
Neoplasm Metastasis - pathology
Neoplasms - genetics
Neoplasms - pathology
Organotropic metastasis
Premetastatic niche
Tumor derived exosomes
Tumor Microenvironment - genetics
Cancer-associated fibroblasts
Premetastatic niche
Organotropic metastasis
EMT
Tumor derived exosomes
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Summary:Abstract Exosomes are small membrane vesicles with a size ranging from 40 to 100 nm. They can serve as functional mediators in cell interaction leading to cancer metastasis. Metastasis is a complex multistep process of cancer cell invasion, survival in blood vessels, attachment to and colonization of the host organ. Exosomes influence every step of this cascade and can be targeted by oncological treatment. This review highlights the role of exosomes in the various steps of the metastatic cascade and how exosome dependent pathways can be targeted as therapeutic approach or used for liquid biopsies.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2017.02.006