Antimicrobial agents of 4-methoxysalicylaldehyde isolated from Periploca sepium oil against foodborne bacteria: structure–activity relationship

• Published in: Applied biological chemistry Vol. 61; no. 4; pp. 397 - 402
• Main Authors: Jeong, Eun-Young, Lee, Myung-Ji, Kang, Min-Seung, Lee, Hoi-Seon
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.08.2018; Springer Nature B.V; 한국응용생명화학회
• Subjects: anti-infective agents; antibacterial properties; Antiinfectives and antibacterials; Antimicrobial activity; Antimicrobial agents; Applied Microbiology; Bacteria; Biological Techniques; Bioorganic Chemistry; Chemistry; Chemistry and Materials Science; Chromatography; Derivatives; Essential oils; Food irradiation; hydroxybenzaldehyde; Listeria; Listeria monocytogenes; Microorganisms; Minimum inhibitory concentration; oils; Periploca; Periploca sepium; roots; Salmonella; Salmonella Typhimurium; Shigella flexneri; Staphylococcus intermedius; structure-activity relationships; 농학; 4-Methoxysalicylaldehyde; Antimicrobial agent; Foodborne bacteria
• ISSN: 2468-0834; 1738-2203; 2468-0842
• DOI: 10.1007/s13765-018-0373-5

This study was designed to evaluate the antimicrobial activities of 4-methoxysalicylaldehyde isolated from Periploca sepium and its derivatives against six foodborne bacteria ( Listeria monocytogenes , Salmonella typhimurium , Shigella flexneri , S. sonnei , Staphylococcus intermedius and S. aureus ). Essential oil extracted from P. sepium roots exhibits strong antimicrobial activity against foodborne bacteria. The antimicrobial compound of P. sepium isolated by chromatographic techniques was identified as 4-methoxysalicylaldehyde. To compare the antimicrobial activities of 4-methoxysalicylaldehyde and its derivatives (4-hydroxysalicylaldehyde, salicylaldehyde, 3-methoxysalicylaldehyde, 5-methoxysalicylaldehyde, 3-methylsalicylaldehyde, and 5-methylsalicylaldehyde), the MIC test was performed. These activities were exhibited by 4-methoxysalicylaldehyde (MIC 30.1–67.3 μg/mL) followed by 4-hydroxysalicylaldehyde (MIC 41.1–61.5 μg/mL) and 4-methoxysalicylaldehyde (MIC 41.3–92.1 μg/mL) against all tested microorganisms. The results indicate that 4-methoxysalicylaldehyde and its derivatives represent natural antimicrobial alternatives.