Absorption of iron from ferric hydroxypyranone complexes
The absorption of 59Fe from preparations of FeSO4 and the ferric hydroxypyranone complexes maltol and ethyl maltol was studied by whole-body counting in normal subjects and patients with Fe deficiency. Fe in the Fe3+ complexes was in general absorbed almost as well as Fe2+. It is concluded that the...
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| Published in | British journal of nutrition Vol. 71; no. 2; pp. 203 - 207 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Cambridge, UK
Cambridge University Press
01.02.1994
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| Subjects | |
| Online Access | Get full text |
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| Abstract | The absorption of 59Fe from preparations of FeSO4 and the ferric hydroxypyranone complexes maltol and ethyl maltol was studied by whole-body counting in normal subjects and patients with Fe deficiency. Fe in the Fe3+ complexes was in general absorbed almost as well as Fe2+. It is concluded that the absorption of Fe3+ from hydroxypyranone complexes is much greater than that from simple Fe3+ salts; this may prove an efficient and less toxic form of Fe for the treatment of deficiency. |
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| AbstractList | The absorption of 59Fe from preparations of FeSO4 and the ferric hydroxypyranone complexes maltol and ethyl maltol was studied by whole-body counting in normal subjects and patients with Fe deficiency. Fe in the Fe3+ complexes was in general absorbed almost as well as Fe2+. It is concluded that the absorption of Fe3+ from hydroxypyranone complexes is much greater than that from simple Fe3+ salts; this may prove an efficient and less toxic form of Fe for the treatment of deficiency. The absorption of 59 Fe from preparations of FeSO 4 and the ferric hydroxypyranone complexes maltol and ethyl maltol was studied by whole-body counting in normal subjects and patients with Fe deficiency. Fe in the Fe 3+ complexes was in general absorbed almost as well as Fe 2+ . It is concluded that the absorption of Fe 3+ from hydroxypyranone complexes is much greater than that from simple Fe 3+ salts; this may prove an efficient and less toxic form of Fe for the treatment of deficiency. The absorption of 59Fe from preparations of FeSO4 and the ferric hydroxypyranone complexes maltol and ethyl maltol was studied by whole-body counting in normal subjects and patients with Fe deficiency. Fe in the Fe3+ complexes was in general absorbed almost as well as Fe2+. It is concluded that the absorption of Fe3+ from hydroxypyranone complexes is much greater than that from simple Fe3+ salts; this may prove an efficient and less toxic form of Fe for the treatment of deficiency.The absorption of 59Fe from preparations of FeSO4 and the ferric hydroxypyranone complexes maltol and ethyl maltol was studied by whole-body counting in normal subjects and patients with Fe deficiency. Fe in the Fe3+ complexes was in general absorbed almost as well as Fe2+. It is concluded that the absorption of Fe3+ from hydroxypyranone complexes is much greater than that from simple Fe3+ salts; this may prove an efficient and less toxic form of Fe for the treatment of deficiency. |
| Author | Hider, R. C. Thompson, R. P. H. Maxton, D. G. |
| Author_xml | – sequence: 1 givenname: D. G. surname: Maxton fullname: Maxton, D. G. organization: Gastrointestinal Laboratory, The Rayne Institute, St Thoinas' Hospital, London SE1 7EH – sequence: 2 givenname: R. P. H. surname: Thompson fullname: Thompson, R. P. H. organization: Gastrointestinal Laboratory, The Rayne Institute, St Thoinas' Hospital, London SE1 7EH – sequence: 3 givenname: R. C. surname: Hider fullname: Hider, R. C. organization: Department of Pharmacy, King's College, University of London, London SW3 60X |
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| Cites_doi | 10.1135/cccc19684198 10.1016/0006-2952(86)90346-1 10.1093/ajcn/49.6.1274 10.1111/j.1365-2710.1991.tb00292.x 10.1001/jama.1984.03340390040026 10.1016/S0079-6468(08)70363-1 10.1111/j.0954-6820.1966.tb19403.x 10.1016/0006-2952(88)90556-4 10.1111/j.2042-7158.1987.tb06249.x 10.1152/physrev.1973.53.3.724 10.1021/jf60173a036 |
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| Keywords | Iron Man Anaemia Ferric hydroxypyranone Human Chemotherapy Iron III Molecular form Absorption Treatment Molecular complex Bioavailability Pyranone derivatives Nutritional deficiency |
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| References | Hurrell (S0007114594000267_ref010) 1985 Dietzfelbinger (S0007114594000267_ref003) 1987; 37 Pagella (S0007114594000267_ref014) 1984; 34 Hallberg (S0007114594000267_ref007) 1966; 181 S0007114594000267_ref017 Heinrich (S0007114594000267_ref008) 1987; 37 Schneider (S0007114594000267_ref016) 1987; 37 S0007114594000267_ref018 S0007114594000267_ref009 S0007114594000267_ref011 Forth (S0007114594000267_ref005) 1987; 37 Gerard (S0007114594000267_ref006) 1980 S0007114594000267_ref013 S0007114594000267_ref002 S0007114594000267_ref001 S0007114594000267_ref012 S0007114594000267_ref015 S0007114594000267_ref004 |
| References_xml | – ident: S0007114594000267_ref018 doi: 10.1135/cccc19684198 – volume: 34 start-page: 952 year: 1984 ident: S0007114594000267_ref014 article-title: Pharmacological and toxicological studies on an iron succinyl-protein complex (ITF282) for oral treatment of iron deficiency anaemia publication-title: Arzneimittel Forschnung – ident: S0007114594000267_ref017 doi: 10.1016/0006-2952(86)90346-1 – ident: S0007114594000267_ref011 doi: 10.1093/ajcn/49.6.1274 – ident: S0007114594000267_ref012 doi: 10.1111/j.1365-2710.1991.tb00292.x – ident: S0007114594000267_ref002 doi: 10.1001/jama.1984.03340390040026 – volume: 37 start-page: 92 year: 1987 ident: S0007114594000267_ref016 article-title: The fate of iron compounds in the gastrointestinal tract publication-title: Arzneimittel Forschnung – ident: S0007114594000267_ref009 doi: 10.1016/S0079-6468(08)70363-1 – volume: 181 start-page: 3 year: 1966 ident: S0007114594000267_ref007 article-title: Side effects of oral iron therapy publication-title: Acta Medica Scandinavica doi: 10.1111/j.0954-6820.1966.tb19403.x – volume: 37 start-page: 96 year: 1987 ident: S0007114594000267_ref005 article-title: Absorption of di- and trivalent iron publication-title: Arzneimittel Forschnung – ident: S0007114594000267_ref013 doi: 10.1016/0006-2952(88)90556-4 – ident: S0007114594000267_ref001 doi: 10.1111/j.2042-7158.1987.tb06249.x – volume: 37 start-page: 105 year: 1987 ident: S0007114594000267_ref008 article-title: Intestinal absorption of 59Fe from neutron-activated commercial oral iron(III)-citrate and iron(III)-hydroxide-polymaltose complexes in man publication-title: Arzneimittel Forschnung – start-page: 44 volume-title: Iron Fortification of Foods year: 1985 ident: S0007114594000267_ref010 – ident: S0007114594000267_ref004 doi: 10.1152/physrev.1973.53.3.724 – start-page: 3927 year: 1980 ident: S0007114594000267_ref006 article-title: Iron complexes of maltol publication-title: Journal of Chemica1 Research – ident: S0007114594000267_ref015 doi: 10.1021/jf60173a036 – volume: 37 start-page: 107 year: 1987 ident: S0007114594000267_ref003 article-title: Bioavailability of bi- and trivalent oral iron preparations publication-title: Arzneimittel Forschnung |
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| Snippet | The absorption of 59Fe from preparations of FeSO4 and the ferric hydroxypyranone complexes maltol and ethyl maltol was studied by whole-body counting in normal... The absorption of 59 Fe from preparations of FeSO 4 and the ferric hydroxypyranone complexes maltol and ethyl maltol was studied by whole-body counting in... |
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| SubjectTerms | Absorption of iron pyrone complexes Adult Aged Anaemia Anemia, Hypochromic - drug therapy Biological and medical sciences Female Ferric Compounds - administration & dosage Ferric Compounds - metabolism Ferric hydroxypyranone Ferrous Compounds - administration & dosage Ferrous Compounds - metabolism General and cellular metabolism. Vitamins Humans Intestinal Absorption - physiology Iron Iron - metabolism Male Man Medical sciences Middle Aged Pharmacology. Drug treatments Pyrones - administration & dosage Pyrones - metabolism Whole-Body Counting |
| Title | Absorption of iron from ferric hydroxypyranone complexes |
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