Absorption of iron from ferric hydroxypyranone complexes

• Published in: British journal of nutrition Vol. 71; no. 2; pp. 203 - 207
• Main Authors: Maxton, D. G., Thompson, R. P. H., Hider, R. C.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.02.1994
• Subjects: Absorption of iron pyrone complexes; Adult; Aged; Anaemia; Anemia, Hypochromic - drug therapy; Biological and medical sciences; Female; Ferric Compounds - administration & dosage; Ferric Compounds - metabolism; Ferric hydroxypyranone; Ferrous Compounds - administration & dosage; Ferrous Compounds - metabolism; General and cellular metabolism. Vitamins; Humans; Intestinal Absorption - physiology; Iron; Iron - metabolism; Male; Man; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Pyrones - administration & dosage; Pyrones - metabolism; Whole-Body Counting; Iron; Man; Anaemia; Ferric hydroxypyranone; Human; Chemotherapy; Iron III; Molecular form; Absorption; Treatment; Molecular complex; Bioavailability; Pyranone derivatives; Nutritional deficiency
• ISSN: 0007-1145; 1475-2662
• DOI: 10.1079/BJN19940127

The absorption of 59Fe from preparations of FeSO4 and the ferric hydroxypyranone complexes maltol and ethyl maltol was studied by whole-body counting in normal subjects and patients with Fe deficiency. Fe in the Fe3+ complexes was in general absorbed almost as well as Fe2+. It is concluded that the absorption of Fe3+ from hydroxypyranone complexes is much greater than that from simple Fe3+ salts; this may prove an efficient and less toxic form of Fe for the treatment of deficiency.