SARS-CoV-2 Spike Protein in Intestinal Cells of a Patient with Coronavirus Disease 2019 Multisystem Inflammatory Syndrome

A previously healthy 12-year-old boy had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related multisystem inflammatory syndrome (MIS-C) that was rapidly fatal. Autopsy revealed the presence of a large intracardiac thrombus. SARS-CoV-2 spike protein was detected in intestinal cells, s...

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Bibliographic Details
Published inThe Journal of pediatrics Vol. 243; pp. 214 - 218.e5
Main Authors Mayordomo-Colunga, Juan, Vivanco-Allende, Ana, López-Alonso, Inés, López-Martínez, Cecilia, Fernández-Vega, Iván, Gil-Peña, Helena, Rey, Corsino
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.04.2022
Subjects
autopsy
Brief Report
Child
COVID-19
COVID-19 - complications
COVID-19 - pathology
Fatal Outcome
Humans
inflammation
Intestines - virology
kawasaki disease
Male
pathology
pathophysiology
SARS-CoV-2
Spike Glycoprotein, Coronavirus
Systemic Inflammatory Response Syndrome
COVID-19
MIS-C
SARS-CoV-2
pathology
inflammation
pathophysiology
autopsy
PICU
kawasaki disease
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Summary:A previously healthy 12-year-old boy had severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related multisystem inflammatory syndrome (MIS-C) that was rapidly fatal. Autopsy revealed the presence of a large intracardiac thrombus. SARS-CoV-2 spike protein was detected in intestinal cells, supporting the hypothesis that viral presence in the gut may be related to the immunologic response of MIS-C.
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2021.11.058