Mapping of Multiple Intestinal Neoplasia ( Min) to Proximal Chromosome 18 of the Mouse

• Published in: Genomics (San Diego, Calif.) Vol. 15; no. 1; pp. 3 - 8
• Main Authors: Luongo, Cindy, Gould, Karen A., Su, Li-Kuo, Kinzler, Kenneth W., Vogelstein, Bert, Dietrich, William, Lander, Eric S., Moser, Amy Rapaich
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 1993; Elsevier
• Subjects: Adenoma - genetics; Animals; Base Sequence; BASIC BIOLOGICAL SCIENCES; Biological and medical sciences; BODY; Chromosome Mapping; CHROMOSOMES; Classical genetics, quantitative genetics, hybrids; Crosses, Genetic; DIGESTIVE SYSTEM; DIMENSIONS; DISEASES; DNA, Single-Stranded; Female; Fundamental and applied biological sciences. Psychology; GASTROINTESTINAL TRACT; GENE MUTATIONS; GENETIC MAPPING; Genetics of eukaryotes. Biological and molecular evolution; Intestinal Neoplasms - genetics; INTESTINES; LARGE INTESTINE; LENGTH; Male; MAPPING; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Mutation; MUTATIONS; NEOPLASMS; Neoplasms, Second Primary - genetics; ORGANS 550400 > Genetics; Polymorphism, Restriction Fragment Length; PROGENY; Vertebrata; Genetic mapping; Animal model; Vertebrata; Mammalia; Mouse; Rodentia; Gut; Homology; Tumor; Adenoma
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1006/geno.1993.1002

The Min ( multiple intestinal neoplasia) mutation of the mouse has been mapped by analyzing the inheritance of restriction fragment length polymorphisms and simple sequence length polymorphisms in progeny from two intraspecific crosses segregating for the Min mutation. Min , a mutant allele of Apc, the mouse homolog of the human APC ( adenomatous polyposis coli) gene, maps to proximal chromosome 18. The synteny between Apc and Mcc, the mouse homolog of the human MCC ( mutated in colorectal cancer) gene, is conserved between mouse and human, although the gene order in the Apc to Mcc interval is different from that in the APC to MCC interval.