Influence of Lavender Essential Oil on the Physical and Antibacterial Properties of Chitosan Sponge for Hemostatic Applications

Uncontrollable bleeding continues to stand as the primary cause of fatalities globally following surgical procedures, traumatic incidents, disasters, and combat scenarios. The swift and efficient management of bleeding through the application of hemostatic agents has the potential to significantly r...

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Published inInternational journal of molecular sciences Vol. 24; no. 22; p. 16312
Main Authors Gheorghiță, Daniela, Antoniac, Iulian, Moldovan, Horațiu, Antoniac, Aurora, Grosu, Elena, Motelica, Ludmila, Ficai, Anton, Oprea, Ovidiu, Vasile, Eugeniu, Dițu, Lia Mara, Raiciu, Anca Daniela
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.11.2023
Subjects
antibacterial activity
Antibacterial agents
Antibiotics
Antimicrobial agents
Bacterial infections
Blood vessels
chitosan
Disease susceptibility
E coli
Escherichia coli
Health aspects
Hemorrhage
hemostatic applications
Infection
Infections
Injuries
lavender essential oil
Microorganisms
Microscopy
Nanoparticles
Oils & fats
Silver
silver nanoparticles
Spectrum analysis
Vibration
Wound healing
Massachusetts
Romania
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Summary:Uncontrollable bleeding continues to stand as the primary cause of fatalities globally following surgical procedures, traumatic incidents, disasters, and combat scenarios. The swift and efficient management of bleeding through the application of hemostatic agents has the potential to significantly reduce associated mortality rates. One significant drawback of currently available hemostatic products is their susceptibility to bacterial infections at the bleeding site. As this is a prevalent issue that can potentially delay or compromise the healing process, there is an urgent demand for hemostatic agents with antibacterial properties to enhance survival rates. To mitigate the risk of infection at the site of a lesion, we propose an alternative solution in the form of a chitosan-based sponge and antimicrobial agents such as silver nanoparticles (AgNPs) and lavender essential oil (LEO). The aim of this work is to provide a new type of hemostatic sponge with an antibacterial barrier against a wide range of Gram-positive and Gram-negative microorganisms: Staphylococcus epidermidis 2018 and Enterococcus faecalis VRE 2566 (Gram-positive strains) and Klebsiella pneumoniae ATCC 10031 and Escherichia coli ATCC 35218 (Gram-negative strains).
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242216312