Ameliorative effect of Allium atroviolaceum on sperm quality in cyclophosphamide-treated mice
Background Cyclophosphamide (CP) is an anti-neoplastic alkylating agent that is extensively used in different chemotherapy regimens. Adverse effects on the reproductive system, especially spermatogenesis, are one of the most important side effects of this drug. It is medically essential to use compl...
Saved in:
Published in | Future journal of pharmaceutical sciences Vol. 7; no. 1; pp. 82 - 11 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.04.2021
Springer Nature B.V SpringerOpen |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Background
Cyclophosphamide (CP) is an anti-neoplastic alkylating agent that is extensively used in different chemotherapy regimens. Adverse effects on the reproductive system, especially spermatogenesis, are one of the most important side effects of this drug. It is medically essential to use complementary and alternative drugs. Herbal drugs have long been used as a complementary treatment. Our purpose was to study the effect of hydroalcoholic
Allium atroviolaceum L.
extract on spermatogenesis in CP-treated mice.
Results
CP affected a significant decrease in sperm count, motility, viability, and morphology. Sperm count was significantly higher in the all extract groups than in the group of control (
p
<0.001) and CP group (
p
<0.001,
p
<0.01). Sperm motility was significantly greater in the extract (100 and 200mg/kg) groups than in the group of control (
p
<0.05 and <0.001). Sperm immotility and rotational movement were significantly higher in the CP group than in the CP+extract groups (
p
<0.001). The sperm viability was significantly greater in the CP+extract (200mg/kg) group than in the CP group (
p
<0.001). The number of headless sperm, sperm with initial tail, with coiled tail, and sperm with curved body, was significantly lower in the CP+extract (200mg/kg) group than in the CP group (
p
<0.001).
Conclusion
A. atroviolaceum
extract treatment significantly improved CP-induced reproductive toxicity. |
---|---|
ISSN: | 2314-7253 2314-7245 2314-7253 |
DOI: | 10.1186/s43094-021-00234-2 |