3-Alkynyl selenophene protects against carbon-tetrachloride-induced and 2-nitropropane-induced hepatic damage in rats

• Published in: Cell biology and toxicology Vol. 26; no. 6; pp. 569 - 577
• Main Authors: Wilhelm, Ethel Antunes, Jesse, Cristiano Ricardo, Prigol, Marina, Alves, Diego, Schumacher, Ricardo Frederico, Nogueira, Cristina Wayne
• Format: Journal Article
• Language: English
• Published: Dordrecht Dordrecht : Springer Netherlands 01.12.2010; Springer Netherlands; Springer Nature B.V
• Subjects: 2-Nitropropane; Alkynes - pharmacology; Alkynes - therapeutic use; Animals; Antioxidant; Antioxidants; Ascorbic Acid - metabolism; Biochemistry; Biomedical and Life Sciences; carbon tetrachloride; Carbon Tetrachloride - toxicity; Catalase - metabolism; Cell Biology; Chemical and Drug Induced Liver Injury - drug therapy; Chemical and Drug Induced Liver Injury - metabolism; Hazardous materials; Life Sciences; Lipid Peroxidation - drug effects; Liver; Liver - anatomy & histology; Liver - drug effects; Liver - metabolism; Male; Nitroparaffins - toxicity; Organoselenium Compounds - pharmacology; Organoselenium Compounds - therapeutic use; Peroxidation; Pharmacology/Toxicology; Propane - analogs & derivatives; Propane - toxicity; Protective Agents - pharmacology; Protective Agents - therapeutic use; Rats; Rats, Wistar; Rodents; Selenium; Toxicology; Selenium; Antioxidant; Carbon tetrachloride; Liver; 2-Nitropropane
• ISSN: 0742-2091; 1573-6822
• DOI: 10.1007/s10565-010-9164-4

The aim of this study was to investigate the protective effect of 3-alkynyl selenophene (3-ASP) on acute liver injury induced by carbon tetrachloride (CCl₄) and 2-nitropropane (2-NP) in rats. On the first day of treatment, the animals received 3-ASP (25 mg/kg, p.o.). On the second day, the rats received CCl₄ (1 mg/kg, i.p.) or 2-NP (100 mg/kg, p.o.). Twenty-four hours after CCl₄ or 2-NP administration, the animals were euthanized, and their plasma and liver were removed for biochemical and histological analyses. The histological analysis revealed extensive injury in the liver of CCl₄-exposed and 2-NP-exposed rats, which was attenuated by 3-ASP. 3-ASP significantly attenuated (1) the increase in plasmatic aspartate and alanine aminotransferase activities and lipid peroxidation levels induced by CCl₄ and 2-NP; (2) the inhibition of δ-aminolevulinic dehydratase activity caused by 2-NP; and (3) the decrease in ascorbic acid (AA) levels and catalase (CAT) activity caused by CCl₄. AA levels and CAT activity remained unaltered in the liver of rats exposed to 2-NP. The protective effect of 3-ASP on acute liver injury induced by CCl₄ and 2-NP in rats was demonstrated.