Xenopus Zic family and its role in neural and neural crest development
We characterized two new members of the Zic family, Xenopus Zic1 and Zic2. They are very similar to mouse Zic1 and Zic2 in the protein coding region including the zinc finger domain. In early gastrula, Zic1 expression was restricted to the prospective neural plate region whereas Zic2 was expressed w...
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Published in | Mechanisms of development Vol. 75; no. 1; pp. 43 - 51 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Ireland
Elsevier Ireland Ltd
01.07.1998
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Subjects | |
Online Access | Get full text |
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Summary: | We characterized two new members of the
Zic family,
Xenopus Zic1 and
Zic2. They are very similar to mouse Zic1 and Zic2 in the protein coding region including the zinc finger domain. In early gastrula,
Zic1 expression was restricted to the prospective neural plate region whereas
Zic2 was expressed widely in the ectoderm. We observed enhanced neural and neural crest-derived tissue formation in the
Zic1 or
Zic2 overexpressed embryos and neural and neural crest marker induction in the
Zic1 or
Zic2 overexpressed animal cap explants. Our findings suggest that
Zic1 and
Zic2 have essentially the same properties as
Zic3 and that the
Xenopus Zic family may act cooperatively in the initial phase of neural and neural crest development. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0925-4773 1872-6356 |
DOI: | 10.1016/S0925-4773(98)00073-2 |