Automated methods for the location of the boundaries of chromatographic peaks

Several simple techniques are presented for the identification of the boundaries of chromatographic peaks. These methods provide a significant reduction in the time needed to perform the rapid, automatic calculation of the central peak moments and to evaluate the quality of a separation while improv...

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Bibliographic Details
Published inJournal of Chromatography A Vol. 1218; no. 45; pp. 8255 - 8263
Main Authors Stevenson, Paul G., Gritti, Fabrice, Guiochon, Georges
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 11.11.2011
Subjects
Automated data analysis
Automatic Data Processing - methods
Boundaries
Chromatography
Chromatography, High Pressure Liquid
Column efficiency
Computational efficiency
Computing time
First peak moment
Mathematical analysis
Models, Theoretical
Naphthalenes
Noise
Peak area
Peak boundaries
Position (location)
Reproducibility of Results
Second peak moment
Separation
Signal Processing, Computer-Assisted
Signal-To-Noise Ratio
Toluidines
Column efficiency
Second peak moment
Automated data analysis
First peak moment
Peak area
Peak boundaries
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Summary:Several simple techniques are presented for the identification of the boundaries of chromatographic peaks. These methods provide a significant reduction in the time needed to perform the rapid, automatic calculation of the central peak moments and to evaluate the quality of a separation while improving the accuracy of the measurements of column efficiencies. It was found that the identification of the peak boundaries as functions of the peak widths and the examination of the slope of the signal to noise versus time plot are viable alternatives to a manual determination.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0021-9673
1873-3778
DOI:10.1016/j.chroma.2011.08.088