A case of respiratory depression in a child with ultrarapid CYP2D6 metabolism after tramadol

We discuss a case of severe respiratory depression in a child, with ultrarapid CYP2D6 genotype and obstructive sleep apnea syndrome, after taking tramadol for pain relief related to a day-case tonsillectomy.

Saved in:
Bibliographic Details
Published inPediatrics (Evanston) Vol. 135; no. 3; p. e753
Main Authors Orliaguet, Gilles, Hamza, Jamil, Couloigner, Vincent, Denoyelle, Françoise, Loriot, Marie-Anne, Broly, Franck, Garabedian, Erea Noel
Format Journal Article
LanguageEnglish
Published United States 01.03.2015
Subjects
Analgesics, Opioid - adverse effects
Analgesics, Opioid - therapeutic use
Child, Preschool
Cytochrome P-450 CYP2D6 - drug effects
Cytochrome P-450 CYP2D6 - genetics
Cytochrome P-450 CYP2D6 - metabolism
Genotype
Humans
Male
Pain, Postoperative - drug therapy
Respiratory Insufficiency - enzymology
Respiratory Insufficiency - etiology
Tonsillectomy
Tramadol - adverse effects
Tramadol - therapeutic use
tramadol
respiratory depression
ultrarapid CYP2D6
Online AccessGet more information

Cover

More Information
Summary:We discuss a case of severe respiratory depression in a child, with ultrarapid CYP2D6 genotype and obstructive sleep apnea syndrome, after taking tramadol for pain relief related to a day-case tonsillectomy.
ISSN:1098-4275
DOI:10.1542/peds.2014-2673