Tumor Microenvironment and Differential Responses to Therapy

• Published in: Cold Spring Harbor perspectives in medicine Vol. 7; no. 7; p. a026781
• Main Authors: Hirata, Eishu, Sahai, Erik
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 01.07.2017
• Subjects: Drug Therapy; Extracellular Matrix; Humans; Neoplasms - pathology; Neoplasms - therapy; Radiotherapy; Tumor Microenvironment

Cancer evolution plays a key role in both the development of tumors and their response to therapy. Like all evolutionary processes, tumor evolution is shaped by the environment. In tumors, this consists of a complex mixture of nontransformed cell types and extracellular matrix. Chemotherapy or radio...