Tumor Microenvironment and Differential Responses to Therapy

Cancer evolution plays a key role in both the development of tumors and their response to therapy. Like all evolutionary processes, tumor evolution is shaped by the environment. In tumors, this consists of a complex mixture of nontransformed cell types and extracellular matrix. Chemotherapy or radio...

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Bibliographic Details
Published inCold Spring Harbor perspectives in medicine Vol. 7; no. 7; p. a026781
Main Authors Hirata, Eishu, Sahai, Erik
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.07.2017
Subjects
Drug Therapy
Extracellular Matrix
Humans
Neoplasms - pathology
Neoplasms - therapy
Radiotherapy
Tumor Microenvironment
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Summary:Cancer evolution plays a key role in both the development of tumors and their response to therapy. Like all evolutionary processes, tumor evolution is shaped by the environment. In tumors, this consists of a complex mixture of nontransformed cell types and extracellular matrix. Chemotherapy or radiotherapy imposes further strong selective pressures on cancer cells during cancer treatment. Here, we review how different components of the tumor microenvironment can modulate the response to chemo- and radiotherapy. We further describe how therapeutic strategies directly alter the composition, or function, of the tumor microenvironment, thereby further altering the selective pressures to which cancer cells are exposed. Last, we explore the consequences of these interactions for therapy outcomes and how to exploit our increasing understanding of the tumor microenvironment for therapeutic benefit.
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ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a026781