Glucose-6-phosphate dehydrogenase deficiency accelerates arterial aging in diabetes

• Published in: Acta diabetologica Vol. 61; no. 1; pp. 127 - 130
• Main Authors: Scuteri, Angelo, Morrell, Christopher H., AlGhatrif, Majd, Orru, Marco, Fiorillo, Edoardo, Marongiu, Michele, Schlessinger, David, Cucca, Francesco, Lakatta, Edward G.
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.01.2024; Springer Nature B.V
• Subjects: Aging; Blood Glucose; Diabetes; Diabetes mellitus; Diabetes Mellitus - epidemiology; Erythrocytes; Glucosephosphate dehydrogenase; Glucosephosphate Dehydrogenase Deficiency - epidemiology; Humans; Inflammation; Interleukin 6; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; Original; Original Article; Pulse Wave Analysis; Vascular Stiffness; Interleukin 6; Aging; Pulse wave velocity; Diabetes; Arterial stiffness; Glucose 5 phosphate dehydrogenase
• ISSN: 1432-5233; 0940-5429; 1432-5233
• DOI: 10.1007/s00592-023-02118-8

Aims High glucose levels and Glucose-6-Phosphate Dehydrogenase deficiency (G6PDd) have both tissue inflammatory effects. Here we determined whether G6PDd accelerates arterial aging (information linked stiffening) in diabetes. Methods Plasma glucose, interleukin 6 (IL6), and arterial stiffness (indexed as carotid-femoral Pulse Wave Velocity, PWV) and red blood cell G6PD activity were assessed in a large (4448) Sardinian population. Results Although high plasma glucose in diabetics , did not differ by G6DP status (178.2 ± 55.1 vs 169.0 ± 50.1 mg/dl) in G6DPd versus non-G6PDd subjects, respectively, IL6, and PWV (adjusted for age and glucose) were significantly increased in G6PDd vs non-G6PDd subjects (PWV, 8.0 ± 0.4 vs 7.2 ± 0.2 m/sec) and (IL6, 6.9 ± 5.0 vs 4.2 ± 3.0 pg/ml). In non-diabetics , neither fasting plasma glucose, nor IL6, nor PWV were impacted by G6PDd. Conclusion G6PDd in diabetics is associated with increased inflammatory markers and accelerated arterial aging.