Orphan opioid receptor antisense probes block orphanin FQ-induced hyperphagia

Orphanin FQ/nociceptin binds with high affinity to the orphan opioid receptor-like/ κ-3 (ORL1/KOR-3) clone, and stimulates feeding. The present study demonstrated that antisense oligodeoxynucleotides directed against either exons 1, 2 or 3 of the ORL1/KOR-3 clone reduced orphanin FQ/nociceptin-induc...

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Published inEuropean journal of pharmacology Vol. 349; no. 1; pp. R1 - R3
Main Authors Leventhal, Liza, Mathis, John P, Rossi, Grace C, Pasternak, Gavril W, Bodnar, Richard J
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 15.05.1998
Subjects
Animals
Eating - drug effects
Exons
Hyperphagia
Hyperphagia - chemically induced
Hyperphagia - physiopathology
Male
Naltrexone - pharmacology
Narcotic Antagonists - pharmacology
Nociceptin
Nociceptin Receptor
Oligonucleotides, Antisense - pharmacology
Opioid Peptides - toxicity
ORL1/KOR-3 clone
Orphanin FQ/nociceptin
Rats
Rats, Sprague-Dawley
Receptors, Opioid - genetics
Receptors, Opioid - physiology
Orphanin FQ/nociceptin
ORL1/KOR-3 clone
Hyperphagia
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Summary:Orphanin FQ/nociceptin binds with high affinity to the orphan opioid receptor-like/ κ-3 (ORL1/KOR-3) clone, and stimulates feeding. The present study demonstrated that antisense oligodeoxynucleotides directed against either exons 1, 2 or 3 of the ORL1/KOR-3 clone reduced orphanin FQ/nociceptin-induced hyperphagia. A missense probe was ineffective. Naltrexone dose-dependently reduced orphanin FQ/nociceptin-induced hyperphagia. These data suggest that the receptor responsible for orphanin FQ/nociceptin-induced hyperphagia is encoded by the ORL1/KOR-3 clone.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(98)00272-6