Treatment of Acquired Epileptic Aphasia With the Ketogenic Diet

Acquired epileptic aphasia remains a poorly understood entity, which is frequently difficult to treat. Previously described treatment modalities have included antiepileptic drugs, corticosteroids, intravenous immunoglobulin, and multiple subpial transections. We describe three patients with acquired...

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Published inJournal of child neurology Vol. 14; no. 11; pp. 696 - 701
Main Authors Christina Bergqvist, A.G., Chee, Claire M., Lutchka, Lisa M., Brooks-Kayal, Amy R.
Format Journal Article
LanguageEnglish
Published Thousand Oaks, CA Sage Publications 01.11.1999
SAGE PUBLICATIONS, INC
Subjects
3-Hydroxybutyric Acid - blood
Adolescent
Anticonvulsants - therapeutic use
Aphasia - etiology
Child
Combined Modality Therapy
Dietary Fats
Electroencephalography
Epilepsy - blood
Epilepsy - complications
Epilepsy - diet therapy
Epilepsy - drug therapy
Epilepsy - urine
Female
Humans
Ketones - urine
Ketosis
Language Acquisition
Language Skills
Male
Remission Induction
Seizures
Treatment Outcome
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Summary:Acquired epileptic aphasia remains a poorly understood entity, which is frequently difficult to treat. Previously described treatment modalities have included antiepileptic drugs, corticosteroids, intravenous immunoglobulin, and multiple subpial transections. We describe three patients with acquired epileptic aphasia refractory to traditional treatments who were successfully treated with the ketogenic diet. All three patients had lasting improvement of their language, behavior, and seizures for 26, 24, and 12 months, respectively. This is the first reported series of patients with acquired epileptic aphasia successfully treated with the ketogenic diet, and suggests a new therapeutic alternative for patients with this often difficult-to-treat disorder. (J Child Neurol 1999;14:696-701).
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ISSN:0883-0738
1708-8283
DOI:10.1177/088307389901401102