Localization of the Gene-Encoding Upstream Stimulatory Factor (USF) to Human Chromosome 1q22-q23

• Published in: Genomics (San Diego, Calif.) Vol. 16; no. 1; pp. 266 - 268
• Main Authors: Shieh, Bie-Huoy, Sparkes, Robert S., Gaynor, Richard B., Lusis, Aldons J.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.04.1993; Elsevier
• Subjects: 550400 - Genetics; ANIMAL CELLS; Animals; Base Sequence; BASIC BIOLOGICAL SCIENCES; Biological and medical sciences; chromosome 1; Chromosome Mapping; CHROMOSOMES; Chromosomes, Human, Pair 1; Classical genetics, quantitative genetics, hybrids; DNA - genetics; DNA HYBRIDIZATION; DNA Probes; DNA-Binding Proteins - genetics; Fundamental and applied biological sciences. Psychology; gene mapping; GENE REPRESSORS; GENES; Genetics of eukaryotes. Biological and molecular evolution; Human; HUMAN CHROMOSOMES; Humans; Hybrid Cells; HYBRIDIZATION; In Situ Hybridization; man; MAPPING; Mice; Molecular Sequence Data; SOMATIC CELLS; TRANSCRIPTION FACTORS; Transcription Factors - genetics; upstream stimulatory factor; Upstream Stimulatory Factors; Genetic mapping; Human; Transcription factor; A1-Chromosome
• ISSN: 0888-7543; 1089-8646
• DOI: 10.1006/geno.1993.1174

The upstream stimulatory factor, USF, is a ubiquitously expressed cellular transcription factor that binds to a symetrical DNA sequence that is found in a variety of viral and cellular promoters. A full-length cDNA encoding the 43-kDa USF protein has previously been isolated. USF contains both helix-loop-helix and leucine repeats, which are involved in regulating its DNA binding and dimerization properties. We report the use of mouse-human somatic cell hybrids and in situ hybridization in localizing the gene-encoding USF to human chromosome 1q22-q23.