Rational use of antibiotics for perforated appendicitis in childhood

Gangrenous and perforated appendicitis was reviewed in 300 pediatric patients. Those with only gangrene generally had a benign course regardless of whether antibiotic therapy was used. However, patients with local perforation or generalized peritonitis had a high incidence of infective complications...

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Bibliographic Details
Published inJournal of pediatric surgery Vol. 17; no. 5; pp. 494 - 500
Main Authors David, Irving B., Buck, James R., Filler, Robert M.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.10.1982
Subjects
Abscess - drug therapy
Adolescent
Ampicillin - therapeutic use
Anti-Bacterial Agents - therapeutic use
Appendicitis
Appendicitis - pathology
Appendicitis - surgery
Child
Child, Preschool
Clindamycin - therapeutic use
Drug Therapy, Combination
Female
Gangrene
Gentamicins - therapeutic use
Humans
Infant
Intestinal Perforation - pathology
Intestinal Perforation - surgery
Length of Stay
Male
Peritoneal Diseases - drug therapy
Surgical Wound Infection - drug therapy
Appendicitis
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Summary:Gangrenous and perforated appendicitis was reviewed in 300 pediatric patients. Those with only gangrene generally had a benign course regardless of whether antibiotic therapy was used. However, patients with local perforation or generalized peritonitis had a high incidence of infective complications if they were not treated with antibiotics. Children treated with ampicillin, gentamicin, and clindamycin had markedly fewer wound infections and abscesses and were able to tolerate a diet and go home sooner than those receiving ampicillin and/or gentamicin.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-3468
1531-5037
DOI:10.1016/S0022-3468(82)80096-1