In Vitro Evaluation of the Feasibility of Commercial Zn Alloys as Biodegradable Metals

• Published in: Journal of materials science & technology Vol. 32; no. 9; pp. 909 - 918
• Main Authors: Wang, C., Yang, H.T., Li, X., Zheng, Y.F.
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.09.2016
• Subjects: Alloys; Biocompatibility; Biodegradability; Biodegradable metals; Commercial Zn alloys; Corrosion behaviors; Corrosion inhibitors; Corrosion rate; Cytotoxicity; Hemocompatibility; Mechanical properties; Morphology; Zinc base alloys; 体外; 可生物降解; 商业用; 生物相容性; 血液相容性; 评价; 金属; 锌合金; Mechanical properties; Cytotoxicity; Commercial Zn alloys; Biodegradable metals; Corrosion behaviors; Hemocompatibility
• ISSN: 1005-0302; 1941-1162
• DOI: 10.1016/j.jmst.2016.06.003

In this work, three widely used commercial Zn alloys （ZA4-1, ZA4-3, ZA6-1 ） were purchased and pre- pared by hot extrusion at 200℃. The microstructure, mechanical properties, corrosion behaviors, biocompatibility and hemocompatibility of Zn alloys were studied with pure Zn as control, Commercial Zn alloys demonstrated increased strength and superb elongation compared with pure Zn. Accelerated corrosion rates and uniform corrosion morphologies were observed in terms of commercial Zn alloys due to galvanic effects between Zn matrix and α-Al phases. 100% extracts of ZA4-1 and ZA6-1 alloys showed mild cytotoxicity while 50% extracts of all samples displayed good biocompatibility. Retardant cell cycle and inhibited stress fibers expression were observed induced by high concentration of Zn^2＋ releasing during corrosion. The hemolysis ratios of Zn alloys were lower than 1% while the adhered platelets showed slightly activated morphologies. In general, commercial Zn alloys possess promising mechanical properties, appropriate corrosion rates, significantly improved biocompatibility and good hemocompatibility in comparison to pure Zn. It is feasible to develop biodegradable metals based on commercial Zn alloys.