Guidelines for the role of autophagy in drug delivery vectors uptake pathways

• Published in: Heliyon Vol. 10; no. 9; p. e30238
• Main Author: Dowaidar, Moataz
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.05.2024; Elsevier
• Subjects: Autophagy; Cellular Trafficking; Drug delivery; Extracellular Vesicles; Nano-delivery Systems; Nanocarriers; Nanotechnology; Organelle Specificity; Selective Autophagy; Targeted Therapy; Therapeutic Nanoparticles; Uptake pathways; Vectors; Nano-delivery Systems; Extracellular Vesicles; Drug delivery; Vectors; Targeted Therapy; Therapeutic Nanoparticles; Autophagy; Selective Autophagy; Cellular Trafficking; Organelle Specificity; Uptake pathways; Nanocarriers; Nanotechnology
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2024.e30238

The process of autophagy refers to the intracellular absorption of cytoplasm (such as proteins, nucleic acids, tiny molecules, complete organelles, and so on) into the lysosome, followed by the breakdown of that cytoplasm. The majority of cellular proteins are degraded by a process called autophagy, which is both a naturally occurring activity and one that may be induced by cellular stress. Autophagy is a system that can save cells' integrity in stressful situations by restoring metabolic basics and getting rid of subcellular junk. This happens as a component of an endurance response. This mechanism may have an effect on disease, in addition to its contribution to the homeostasis of individual cells and tissues as well as the control of development in higher species. The main aim of this study is to discuss the guidelines for the role of autophagy in drug delivery vector uptake pathways. In this paper, we discuss the meaning and concept of autophagy, the mechanism of autophagy, the role of autophagy in drug delivery vectors, autophagy-modulating drugs, nanostructures for delivery systems of autophagy modulators, etc. Later in this paper, we talk about how to deliver chemotherapeutics, siRNA, and autophagy inducers and inhibitors. We also talk about how hard it is to make a drug delivery system that takes nanocarriers' roles as autophagy modulators into account.