New Therapeutic Strategies for Obesity and Its Metabolic Sequelae: Brazilian Cerrado as a Unique Biome

• Published in: International journal of molecular sciences Vol. 24; no. 21; p. 15588
• Main Authors: Monteiro-Alfredo, Tamaeh, Macedo, Maria Lígia Rodrigues, de Picoli Souza, Kely, Matafome, Paulo
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.11.2023
• Subjects: Adipocytes; Biodiversity; Biomes; Body mass index; Cell cycle; Cerrado ecosystem; Chronic illnesses; Dextrose; Enzymes; ethnopharmacology; Fatty acids; Flavonoids; Free radicals; Glucose; Health aspects; Insulin resistance; Kinases; Life expectancy; Lipids; Medicinal plants; Medicine, Botanic; Medicine, Herbal; metabolic diseases; Metabolic disorders; Metabolites; Native species; Obesity; Overweight; Oxidation; phytochemical compounds; Phytochemicals; Political aspects; Polyphenols; Public policy; Quality of life; secondary metabolites; Toxicity; Type 2 diabetes; Brazil
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms242115588

Brazil has several important biomes holding impressive fauna and flora biodiversity. Cerrado being one of the richest ones and a significant area in the search for new plant-based products, such as foods, cosmetics, and medicines. The therapeutic potential of Cerrado plants has been described by several studies associating ethnopharmacological knowledge with phytochemical compounds and therapeutic effects. Based on this wide range of options, the Brazilian population has been using these medicinal plants (MP) for centuries for the treatment of various health conditions. Among these, we highlight metabolic diseases, namely obesity and its metabolic alterations from metabolic syndrome to later stages such as type 2 diabetes (T2D). Several studies have shown that adipose tissue (AT) dysfunction leads to proinflammatory cytokine secretion and impaired free fatty acid (FFA) oxidation and oxidative status, creating the basis for insulin resistance and glucose dysmetabolism. In this scenario, the great Brazilian biodiversity and a wide variety of phytochemical compounds make it an important candidate for the identification of pharmacological strategies for the treatment of these conditions. This review aimed to analyze and summarize the current literature on plants from the Brazilian Cerrado that have therapeutic activity against obesity and its metabolic conditions, reducing inflammation and oxidative stress.