Elevated lactate dehydrogenase predicts pneumonia in spontaneous intracerebral hemorrhage

• Published in: Heliyon Vol. 10; no. 4; p. e26109
• Main Authors: Xiao, Yangchun, He, Shuanghong, Cheng, Xin, Peng, Liyuan, Tian, Yixin, Li, Tiangui, He, Jialing, Hao, Pengfei, Chong, Weelic, Hai, Yang, You, Chao, Fang, Fang, Peng, Zongjun, Zhang, Yu
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 29.02.2024; Elsevier
• Subjects: Complication; Inflammatory marker; Intracerebral hemorrhage; Lactate dehydrogenase; Pneumonia; Inflammatory marker; Lactate dehydrogenase; Complication; Pneumonia; Intracerebral hemorrhage
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2024.e26109

Although a variety of risk factors for pneumonia after spontaneous intracerebral hemorrhage have been established, an objective and easily obtainable predictor is still needed. Lactate dehydrogenase is a nonspecific inflammatory biomarker. In this study, we aimed to assess the association between lactate dehydrogenase and pneumonia in spontaneous intracerebral hemorrhage patients. Our study was a retrospective, multicenter cohort study, undertaken in 7562 patients diagnosed with spontaneous intracerebral hemorrhage from 3 hospitals. All serum Lactate dehydrogenase was collected within 7 days from admission and divided into four groups as quartile(Q). We conducted a multivariable logistic regression analysis to assess the association of Lactate dehydrogenase with pneumonia. Among a total of 7562 patients, 2971 (39.3%) patients were diagnosed with pneumonia. All grades of elevated lactate dehydrogenase were associated with increased raw and risk-adjusted risk of pneumonia. Multiple logistic regression analysis showed odds ratios for Q2-Q4 compared with Q1 were 1.21 (95% CI, 1.04–1.42), 1.64(95% CI, 1.41–1.92), and 1.92 (95% CI, 1.63–2.25) respectively. The odds ratio after adjustment was 4.42 (95% CI, 2.94–6.64) when lactate dehydrogenase was a continuous variable after log-transformed. Elevated lactate dehydrogenase is significantly associated with an increase in the odds of pneumonia and has a predictive value for severe pneumonia in patients with pneumonia. Lactate dehydrogenase may be used to predict pneumonia events in spontaneous intracerebral hemorrhage patients as a laboratory marker.