The effect of stevioside on blood pressure and plasma catecholamines in spontaneously hypertensive rats
Stevioside is a sweet-tasting glycoside, composed of stevia, a diterpenic carboxylic alcohol with three glucose molecules, mainly used as a substitute for non-alcoholic sweetener. It has previously been shown to reduce blood pressure in studies in animals and human. The effect of intravenous Stevios...
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Published in | Life sciences (1973) Vol. 63; no. 19; pp. 1679 - 1684 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Netherlands
Elsevier Inc
1998
|
Subjects | |
Online Access | Get full text |
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Summary: | Stevioside is a sweet-tasting glycoside, composed of stevia, a diterpenic carboxylic alcohol with three glucose molecules, mainly used as a substitute for non-alcoholic sweetener. It has previously been shown to reduce blood pressure in studies in animals and human. The effect of intravenous Stevioside on the blood pressure was studied in spontaneously hypertensive rats (SHR). The hypotensive effect on both systolic and diastolic blood pressure was dose-dependent for intravenous doses of 50, 100 and 200
mg
kg
in conscious SHR. The maximum reductions in systolic and diastolic blood pressure were 31.4 ± 4.2 % and 40.8 ± 5.6 % (mean ± SEM) respectively and the hypotensive effect lasted for more than 60 min with a dose of 200
mg
kg
. Serum dopamine, norepinephrine and epinephrine levels were not changed significantly 60 min after intravenous injection of Stevioside 100
mg
kg
in anesthetized SHR. The present data show that Stevioside given intravenously to conscious SHR was effective in blood pressure reduction and there was no change in serum catecholamines in anaesthetized animals with this natural compound. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0024-3205 1879-0631 |
DOI: | 10.1016/S0024-3205(98)00439-1 |