Association of genetic polymorphisms with COVID-19 infection and outcomes: An updated meta-analysis based on 62 studies

• Published in: Heliyon Vol. 10; no. 1; p. e23662
• Main Authors: Ren, Hongyue, Lin, Yanyan, Huang, Lifeng, Xu, Wenxin, Luo, Deqing, Zhang, Chunbin
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 15.01.2024; Elsevier
• Subjects: COVID-19; Genetic polymorphisms; Infection; meta-analysis; Outcomes; COVID-19; Infection; meta-analysis; Genetic polymorphisms; Outcomes
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2023.e23662

The relationship between genetic polymorphisms and coronavirus disease 2019 (COVID-19) remains to be inconsistent. This meta-analysis aimed to provide an updated evaluation of the role of genetic polymorphisms in the infection, severity and mortality of COVID-19 based on all available published studies. A systematic search was performed using six databases: PubMed, Embase, Web of Science, Cochrane Library, Chinese National Knowledge Infrastructure (CNKI) and Wanfang. Summary odds ratios (ORs) and corresponding 95 % confidence intervals (CIs) were used to calculate the genotypic comparison. All statistical analyses were conducted in Stata 12.0. A total of 62 studies with 19600 cases and 28899 controls was included in this meta-analysis. For COVID-19 infection, ACE Ins/Del polymorphism might be related with significantly decreased risk of COVID-19 infection under dominant, homozygote and allelic models. Meanwhile, the IFITM3 rs12252 and TMPRSS2 rs12329760 polymorphisms were significantly associated with the increased risk of COVID-19 infection under one or more models. Regarding COVID-19 severity, ACE2 rs2074192, ACE2 rs2106809, IFITM3 rs12252 and VDR rs1544410 polymorphisms might be related with significantly increased risk of COVID-19 severity in one or more models. Moreover, the analysis of TMPRSS2 rs2070788 indicated that a variant A allele decreased the risk of COVID-19 severity in recessive model. For COVID-19 mortality, the variant C allele of IFITM3 rs12252 polymorphism might be related with significantly increased risk of COVID-19 mortality under all genetic models. This meta-analysis indicated that he infection, severity or mortality of COVID-19 were related to the above genetic polymorphisms, which might provide an important theoretical basis for understanding the clinical feature of COVID-19 disease.