Metallo-β-lactamase-producing Pseudomonas aeruginosa in the Netherlands: the nationwide emergence of a single sequence type

Recently, the first outbreak of clonally related VIM-2 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa in a Dutch tertiary-care centre was described. Subsequently, a nationwide surveillance study was performed in 2010–2011, which identified the presence of VIM-2 MBL-producing P. aeruginos...

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Published inClinical microbiology and infection Vol. 18; no. 9; pp. E369 - E372
Main Authors Van der Bij, A.K., Van der Zwan, D., Peirano, G., Severin, J.A., Pitout, J.D.D., Van Westreenen, M., Goessens, W.H.F.
Format Journal Article
LanguageEnglish
Published Oxford, UK Elsevier Ltd 01.09.2012
Blackwell Publishing Ltd
Subjects
Antimicrobial resistance
beta-Lactam Resistance
beta-Lactamases - biosynthesis
beta-Lactamases - genetics
carbapenemase
Cross Infection - microbiology
Genotyping
Hospitals
Humans
Infection
Metallo- beta -lactamase
Microbial Sensitivity Tests
Minisatellite Repeats
molecular epidemiology
Multilocus Sequence Typing
Netherlands
nosocomial transmission
Nucleotide sequence
Phenotype
Pseudomonas aeruginosa
Pseudomonas aeruginosa - classification
Pseudomonas aeruginosa - enzymology
Pseudomonas aeruginosa - genetics
Pseudomonas aeruginosa - isolation & purification
Pseudomonas Infections - microbiology
Retrospective Studies
Netherlands
molecular epidemiology
Pseudomonas aeruginosa
nosocomial transmission
Antimicrobial resistance
carbapenemase
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Summary:Recently, the first outbreak of clonally related VIM-2 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa in a Dutch tertiary-care centre was described. Subsequently, a nationwide surveillance study was performed in 2010–2011, which identified the presence of VIM-2 MBL-producing P. aeruginosa in 11 different hospitals. Genotyping by multiple-locus variable-number tandem-repeat analysis (MLVA) showed that the majority of the 82 MBL-producing isolates found belonged to a single MLVA type (n = 70, 85%), identified as STI11 by multilocus sequence typing (MLST). As MBL-producing isolates cause serious infections that are difficult to treat, the presence of clonally related isolates in various hospitals throughout the Netherlands is of nationwide concern.
Bibliography:for the members of the MBL‐PA surveillance study group.
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ISSN:1198-743X
1469-0691
DOI:10.1111/j.1469-0691.2012.03969.x