Hyperbaric oxygen and photodynamic therapy in the treatment of advanced carcinoma of the cardia and the esophagus
Background and Objective The photochemical reaction of photodynamic therapy (PDT) depends on the presence of molecular oxygen. Because of anoxic regions in tumor tissue and vascular shutdown during PDT, the efficiency is limited. Therefore, the use of hyperbaric oxygen, which increases the oxygen in...
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Published in | Lasers in surgery and medicine Vol. 26; no. 3; pp. 308 - 315 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
New York
John Wiley & Sons, Inc
2000
Wiley-Liss |
Subjects | |
Online Access | Get full text |
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Summary: | Background and Objective
The photochemical reaction of photodynamic therapy (PDT) depends on the presence of molecular oxygen. Because of anoxic regions in tumor tissue and vascular shutdown during PDT, the efficiency is limited. Therefore, the use of hyperbaric oxygen, which increases the oxygen in tumor tissue, as well as the amount of singlet oxygen, may enhance the efficiency of PDT.
Study Design/Materials and Methods
After diagnostic work‐up, photosensitization was carried out with a hematoporphyrin‐derivate 2 mg/kg body weight 48 hours before PDT. The light dose was calculated as 300 J/cm of fiber tip. Twenty‐three patients were treated by PDT alone and 29 patients received PDT under hyperbaric oxygen at a level of two absolute atmospheric pressures.
Results
Improvement regarding dysphagia and stenosis‐diameter could be obtained in both treatment arms with no significant difference (P = 0.43 and P = 0.065, respectively). The tumor length also decreased in both groups and showed a significant difference in favour of the PDT/HBO group (P = 0.002). The mean overall survival was 11.3 months. The mean survival time for the PDT group was 8.7 months and for the PDT/HBO group 13.8 months (P = 0.021).
Conclusion
According to this pilot study, combined PDT/HBO represents a new approach in the treatment of esophageal and cardia cancer, which appears to have enhanced the efficiency of PDT. Lasers Surg. Med. 26:308–315, 2000. © 2000 Wiley‐Liss, Inc. |
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Bibliography: | ark:/67375/WNG-XLZR0TR8-6 istex:51ED2BA3D638363F41A5703293F1117223F5A616 ArticleID:LSM9 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0196-8092 1096-9101 |
DOI: | 10.1002/(SICI)1096-9101(2000)26:3<308::AID-LSM9>3.0.CO;2-B |