Human hepatitis B virus mutants: significance of molecular changes

Human hepatitis B virus, the leading pathogen for hepatitis B, is a compact DNA virus with viral genes that largely overlap. An increasing number of mutations have emerged following human interventions such as vaccination and anti-viral therapy. While vaccine escape mutants are characterized by muta...

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Bibliographic Details
Published inFEBS Letters Vol. 453; no. 3; pp. 237 - 242
Main Authors Chen, Wei Ning, Oon, Chong Jin
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier B.V 25.06.1999
Subjects
Anti-viral therapy
Antiviral Agents - pharmacology
DNA-Directed DNA Polymerase - genetics
Drug Resistance, Microbial
Hepatitis B Core Antigens - genetics
Hepatitis B Surface Antigens - genetics
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Hepatocellular carcinoma
Human hepatitis B virus
Mutation
Trans-Activators - genetics
Vaccine escape
Vaccine escape
Hepatocellular carcinoma
Mutation
Human hepatitis B virus
Anti-viral therapy
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Summary:Human hepatitis B virus, the leading pathogen for hepatitis B, is a compact DNA virus with viral genes that largely overlap. An increasing number of mutations have emerged following human interventions such as vaccination and anti-viral therapy. While vaccine escape mutants are characterized by mutations on the antigenic hepatitis B surface antigen, those carrying mutations in other viral proteins are either resistant to anti-viral therapy or implicated in acute liver diseases. Molecular identification of these various mutants should shed new lights on the underlying mechanism of hepatitis B virus viral escape and resistance and provide helpful information on their effective eradication.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0014-5793
1873-3468
DOI:10.1016/S0014-5793(99)00704-8