Biomimetic Materials for Bone Tissue Engineering - State of the Art and Future Trends

Bone tissue engineering is extremely promising for regenerating large bone defects in orthopedic or maxillofacial surgery. It consists of harvesting, culturing and differentiating human mesenchymal stem cells in combination with scaffolds. Different cell sources, such as bone marrow or adipose tissu...

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Published inAdvanced engineering materials Vol. 13; no. 5; pp. B135 - B150
Main Authors Cordonnier, Thomas, Sohier, Jérôme, Rosset, Philippe, Layrolle, Pierre
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.05.2011
WILEY‐VCH Verlag
Wiley
Subjects
Biocompatibility
Bioengineering
Biomaterials
Biomedical materials
Bones
Culture
In vivo testing
In vivo tests
Life Sciences
Surgical implants
Three dimensional
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Summary:Bone tissue engineering is extremely promising for regenerating large bone defects in orthopedic or maxillofacial surgery. It consists of harvesting, culturing and differentiating human mesenchymal stem cells in combination with scaffolds. Different cell sources, such as bone marrow or adipose tissue, have been studied. Biomaterials resembling bone extracellular matrix have been used for scaffolding cells. However, these macroporous calcium phosphate ceramics or biodegradable polymers are two dimensional structures at the cellular level and have low osteogenesis properties in vivo. In this paper, several biomimetic approaches involving hydrogels or particles for 3‐dimensional (3D) cell cultures are reviewed. High numbers of cells for low amounts of material induced abundant extracellular matrix formation in vitro and relatively large amounts of bone tissue formation in vivo. In addition, the 3D culture of several cell populations should make it easier for bone tissue constructs to vascularize, thus lifting the limits of current clinical applications. Bone tissue engineering consists of culturing mesenchymal stem cells in combination with scaffolds for regenerating bone defects in patients. This paper reviews biomimetic approaches involving hydrogels, polymer nanofibers or calcium phosphate microparticles for 3‐dimensional culture of several cell populations. Hybrid constructs having high numbers of cells and low volume content of biomaterial may facilitate bone tissue regeneration and re‐vascularization.
Bibliography:European Commission - No. 241879
ArticleID:ADEM201080098
istex:2C3A3A6964B0E75202C02AAC4C735A0446C4B6B3
Acknowledgements: This work was funded by a grant from the Directorate-General for research of the European Commission (no. 241879), through the REBORNE project. TC and JS were supported by the French national research agency (ATOS project).
ark:/67375/WNG-5MNQCRP7-7
Acknowledgements: This work was funded by a grant from the Directorate‐General for research of the European Commission (no. 241879), through the REBORNE project. TC and JS were supported by the French national research agency (ATOS project).
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ISSN:1438-1656
1527-2648
1527-2648
DOI:10.1002/adem.201080098