Copper-Catalyzed Synthesis of Imidazo[1,2-a]pyridines through Tandem Imine Formation-Oxidative Cyclization under Ambient Air: One-Step Synthesis of Zolimidine on a Gram-Scale
A new copper‐catalyzed oxidative cyclization via CH amination between 2‐aminopyridines and methyl aryl/heteroaryl ketones has been developed under ambient air. Imidazo[1,2‐a]pyridines containing a wide range of functional groups have been synthesized from basic and easily available starting materia...
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Published in | Advanced synthesis & catalysis Vol. 355; no. 9; pp. 1741 - 1747 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Weinheim
WILEY-VCH Verlag
17.06.2013
WILEY‐VCH Verlag Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | A new copper‐catalyzed oxidative cyclization via CH amination between 2‐aminopyridines and methyl aryl/heteroaryl ketones has been developed under ambient air. Imidazo[1,2‐a]pyridines containing a wide range of functional groups have been synthesized from basic and easily available starting materials. This simple, one‐pot reaction protocol is applicable for the direct preparation of zolimidine (a marketed antiulcer drug) on a large scale. |
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Bibliography: | UGC ArticleID:ADSC201300298 DST Govt. of India - No. SR/S5/GC-05/2010 CSIR istex:B96808E38892DED2BC7F1A9692EC9F3B0E6A2093 UGC-SAP DST-FIST ark:/67375/WNG-QQ1M0MJM-F ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 |
ISSN: | 1615-4150 1615-4169 |
DOI: | 10.1002/adsc.201300298 |