Rapid near IR spectrophotometric determination of meprobamate in pharmaceutical preparations
A rapid near IR spectrophotometric method was developed for determining meprobamate in tablets, sustained-release capsules, suspensions, and injectables. The absorbance of a chloroform solution of the drug is obtained at about 1.96 mum for quantitation. Assay of nine commercial products from four di...
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Published in | Journal of pharmaceutical sciences Vol. 66; no. 2; p. 292 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
01.02.1977
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Subjects | |
Online Access | Get more information |
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Summary: | A rapid near IR spectrophotometric method was developed for determining meprobamate in tablets, sustained-release capsules, suspensions, and injectables. The absorbance of a chloroform solution of the drug is obtained at about 1.96 mum for quantitation. Assay of nine commercial products from four different manufacturers gave results ranging from 97 to 104% of label claim. Coefficients of variation of 0.7 and 1.3% were obtained on the tablets and a sustained-release product, respectively. |
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ISSN: | 0022-3549 |
DOI: | 10.1002/jps.2600660246 |