Rapid near IR spectrophotometric determination of meprobamate in pharmaceutical preparations

A rapid near IR spectrophotometric method was developed for determining meprobamate in tablets, sustained-release capsules, suspensions, and injectables. The absorbance of a chloroform solution of the drug is obtained at about 1.96 mum for quantitation. Assay of nine commercial products from four di...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 66; no. 2; p. 292
Main Authors Zappala, A F, Post, A
Format Journal Article
LanguageEnglish
Published United States 01.02.1977
Subjects
Capsules - analysis
Delayed-Action Preparations - analysis
Injections
Meprobamate - analysis
Solutions - analysis
Spectrophotometry, Infrared
Suspensions - analysis
Tablets - analysis
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Summary:A rapid near IR spectrophotometric method was developed for determining meprobamate in tablets, sustained-release capsules, suspensions, and injectables. The absorbance of a chloroform solution of the drug is obtained at about 1.96 mum for quantitation. Assay of nine commercial products from four different manufacturers gave results ranging from 97 to 104% of label claim. Coefficients of variation of 0.7 and 1.3% were obtained on the tablets and a sustained-release product, respectively.
ISSN:0022-3549
DOI:10.1002/jps.2600660246