Salinomycin poisoning in point-of-lay turkeys [ionophore coccidiostat]
400 birds of a flock of 700 fed a diet containing salinomycin died over 7 days. No gross lesions were detected. Histological myopathy was most readily detected in leg muscles 5 to 7 days after ingestion. In feeding trials, individual susceptibility was found to vary greatly. A marked increase in pla...
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| Published in | Australian veterinary journal Vol. 66; no. 10; p. 326 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
England
01.10.1989
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| Subjects | |
| Online Access | Get more information |
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| Abstract | 400 birds of a flock of 700 fed a diet containing salinomycin died over 7 days. No gross lesions were detected. Histological myopathy was most readily detected in leg muscles 5 to 7 days after ingestion. In feeding trials, individual susceptibility was found to vary greatly. A marked increase in plasma activities of creatine kinase and aspartate amino transferase preceded histological evidence of muscle necrosis. |
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| AbstractList | Salinomycin poisoning occurred in a flock of 700 point-of-lay turkeys; 400 birds died over 7 days as a result of consuming feed contaminated with 50 ppm salinomycin. No gross lesions were detected. Histologic evidence of a myopathy was most readily detected in leg muscles of turkeys 5 to 7 d after ingesting salinomycin. Feeding trials were undertaken and individual susceptibility to the drug was found to vary greatly. In affected birds the plasma concentrations of creatine kinase (CK) and aspartate aminotransferase (AST) were found to be in the range of 500,000 to 2,500,000 IU/l and 9000 to 25,000 IU/l, respectively. The marked increase in the plasma activities of these enzymes preceded histological evidence of segmental muscle necrosis. 400 birds of a flock of 700 fed a diet containing salinomycin died over 7 days. No gross lesions were detected. Histological myopathy was most readily detected in leg muscles 5 to 7 days after ingestion. In feeding trials, individual susceptibility was found to vary greatly. A marked increase in plasma activities of creatine kinase and aspartate amino transferase preceded histological evidence of muscle necrosis. |
| Author | Griffiths, G.L Hillier, P. (Western Australian Dept. of Agriculture, Perth. Animal Health Lab.) Sutherland, R.J. (Murdoch Univ., Murdoch (Australia). School of Veterinary Studies) |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/2818361$$D View this record in MEDLINE/PubMed |
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| Snippet | 400 birds of a flock of 700 fed a diet containing salinomycin died over 7 days. No gross lesions were detected. Histological myopathy was most readily detected... Salinomycin poisoning occurred in a flock of 700 point-of-lay turkeys; 400 birds died over 7 days as a result of consuming feed contaminated with 50 ppm... |
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| SubjectTerms | Animal Feed - poisoning Animals Aspartate Aminotransferases - blood Coccidiostats - poisoning CONTAMINANTES Creatine Kinase - blood DINDON ENVENENAMIENTO Female Food Contamination INTOXICATION Ionophores - poisoning Muscles - pathology PAVO POLLUANT Poultry Diseases - blood Poultry Diseases - chemically induced Poultry Diseases - enzymology Poultry Diseases - pathology Pyrans - poisoning SALINOMICINA SALINOMYCINE Turkeys |
| Title | Salinomycin poisoning in point-of-lay turkeys [ionophore coccidiostat] |
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