A-to-I RNA Editing and Human Disease

The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has beenrecognized as an important mechanism for the generation of molecular diversity and alsoregulates protein function through recoding of genomic information. As the molecular players ofediting are characterized...

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Bibliographic Details
Published inRNA biology Vol. 3; no. 1; pp. 1 - 9
Main Authors Maas, Stefan, Kawahara, Yukio, Tamburro, Kristen M., Nishikura, Kazuko
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.01.2006
Subjects
Adenosine - chemistry
Adenosine - genetics
Amino Acid Sequence
Amyotrophic Lateral Sclerosis - genetics
Animals
Binding
Biology
Bioscience
Calcium
Cancer
Cell
Cycle
Epilepsy - genetics
etiology
genes
genomics
human diseases
Humans
Inosine - chemistry
Inosine - genetics
Landes
mammals
Measles - genetics
messenger RNA
Mice
Models, Genetic
Molecular Sequence Data
Mutation
Organogenesis
phenotype
Proteins
RNA editing
RNA Editing - genetics
RNA Processing, Post-Transcriptional
Skin Diseases - genetics
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Summary:The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has beenrecognized as an important mechanism for the generation of molecular diversity and alsoregulates protein function through recoding of genomic information. As the molecular players ofediting are characterized and an increasing number of genes become identified that are subject toA-to-I modification, the potential impact of editing on the etiology or progression of humandiseases is realized. Here we review the recent knowledge on where disturbances in A-to-I RNAediting have been correlated with human disease phenotypes.
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ISSN:1547-6286
1555-8584
1555-8584
DOI:10.4161/rna.3.1.2495