The effect of age and dose number on the risk of collapse (hypotonic-hyporesponsive episode) after pertussis vaccination

The Netherlands vaccination schedule has been advanced by 1 month. The reporting rate of collapse or hypotonic-hyporesponsive episode increased from 5.2 [95% confidence interval (CI): 4.8-5.7] to 8.5 (95% CI: 8.0-9.1) and from 1.2 (95% CI: 1.0-1.4) to 2.5 (95% CI: 2.2-2.8) per 10,000 first and secon...

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Bibliographic Details
Published inThe Pediatric infectious disease journal Vol. 27; no. 4; p. 355
Main Authors Vermeer-de Bondt, Patricia E, van der Maas, Nicoline A T
Format Journal Article
LanguageEnglish
Published United States 01.04.2008
Subjects
Age Factors
Humans
Infant
Infant, Newborn
Netherlands
Pertussis Vaccine - administration & dosage
Pertussis Vaccine - adverse effects
Syncope
Vaccination - adverse effects
Whooping Cough - prevention & control
Netherlands
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Summary:The Netherlands vaccination schedule has been advanced by 1 month. The reporting rate of collapse or hypotonic-hyporesponsive episode increased from 5.2 [95% confidence interval (CI): 4.8-5.7] to 8.5 (95% CI: 8.0-9.1) and from 1.2 (95% CI: 1.0-1.4) to 2.5 (95% CI: 2.2-2.8) per 10,000 first and second doses, respectively. At 3 months of age it fell from 5.2 to 2.5. This suggests some protection by the first dose. Different mediators in primary and secondary immune response may play a role.
ISSN:0891-3668
1532-0987
DOI:10.1097/INF.0b013e318162a127